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2.B.11 The Calcimycin or A23187 Carrier-type Ionophore (Calcimycin) Family

A23187 or calcimycin is a mobile ion-carrier that forms stable complexes with divalent cations. A23187 is also known as Calcimycin, Calcium Ionophore, Antibiotic A23187 and Calcium Ionophore A23187. It is produced during fermentation of Streptomyces chartreusensis.  It complexes and transports Mn2+ > Ca2+ > Mg2+ >>Sr2+ > Ba2+.  It is used to increase intracellular Ca2+ (Stern 1977).

References associated with 2.B.11 family:

Stern, P.H. (1977). Ionophores. Chemistry, physiology and potential applications to bone biology. Clin Orthop Relat Res 273-298. 65236