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3.A.1.117.2 Hop resistance protein, HorA. Reconstitution in phosphatidyl ethanolamine bilayers resulted in normal activity, but reconstitution in phosphatidyl choline resulted in uncoupling of ATP hydrolysis from transport and a change in the orientations of the TMSs (Gustot et al. 2010).
Accession Number:	O32748
Protein Name:	HorA
Length:	583
Molecular Weight:	64208.00
Species:	Lactobacillus brevis [1580]
Number of TMSs:	5
Location¹ / Topology² / Orientation³:	Cell membrane¹ / Multi-pass membrane protein²
Substrate

Pfam:	PF00664 PF00005
Gene Ontology GO:0016021 C:integral to membrane GO:0005524 F:ATP binding GO:0042626 F:ATPase activity, coupled to transmembrane m... GO:0055085 P:transmembrane transport

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MQAQSKNNTK FNFKTFMGLI NRIHPRYWQL LLGFFLGVVA TAMQLMVPGI AKGIINSIGH 
61:	SMDVGLIVAV ILLFVSSTII GAFSGSILGF FGEDVVYKLR TTLWDKILTL PVGYFDQTKS 
121:	GEITSRLVND STQVKELLAN SVPKTATSIL QLVGALVLML IMDWRMTIIM FIAVPLVLIC 
181:	LLPIVRQSHK VARARQDALA DLNGKAGEML GEVRLVKSST AENLERTAGD KRMYRLYRIG 
241:	LKEAIYDSIA GPVMGMVMMA MVLEILGYGA IRVREGAIDI GTLFSFLMYL VQMISPFAVL 
301:	GQFMSDVAKA SGSTTRIQAL LQTHEEDRLT GTDLDIGDQT LQMNHVSFSY DQHHPILSGV 
361:	SFTAEPNSVI AFAGPSGGGK STISSLIERF YEPNEGSITI GNTNITDIQL ADWRQQIGLV 
421:	GQDAAIMSGT IRYNLTYGLP GHFSDEQLWH VLEMAYATQF VQKMPRGLDT EVGERGVKVS 
481:	GGQRQRLAIA RAFLRNPKIL MLDEATASLD SESEMMVQKA LDQLMANRTT LVIAHRLSTI 
541:	TNADEIYFIE NGRVTGQGTH QQLVKTTPLY REYVKNQSAT SNG

3.A.1.117.2
Hop resistance protein, HorA. Reconstitution in phosphatidyl ethanolamine bilayers resulted in normal activity, but reconstitution in phosphatidyl choline resulted in uncoupling of ATP hydrolysis from transport and a change in the orientations of the TMSs (Gustot et al. 2010).

Cross database links:

Gene Ontology

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3.A.1.117.2 Hop resistance protein, HorA. Reconstitution in phosphatidyl ethanolamine bilayers resulted in normal activity, but reconstitution in phosphatidyl choline resulted in uncoupling of ATP hydrolysis from transport and a change in the orientations of the TMSs (Gustot et al. 2010).

Cross database links:

Gene Ontology

External Searches:

Analyze:

3.A.1.117.2
Hop resistance protein, HorA. Reconstitution in phosphatidyl ethanolamine bilayers resulted in normal activity, but reconstitution in phosphatidyl choline resulted in uncoupling of ATP hydrolysis from transport and a change in the orientations of the TMSs (Gustot et al. 2010).