3.A.1.201.47
Active peptide/heavy metal cation exporter, MDR4 or ABCB4, of 1365 aas and 7 TMSs in a 1 + 2 + 2 + 2 TMS arrangement, followed by a large hydrophilic ATPase domain; it probably has an M-C domain order (Wunderlich 2022).
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| Accession Number: | O77308 |
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| Protein Name: | ABC transporter B family member 4, putative |
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| Length: | 1365 |
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| Molecular Weight: | 161242.00 |
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| Species: | Plasmodium falciparum (isolate 3D7) [36329] |
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| Number of TMSs: | 4 |
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| Substrate |
metal cation, peptide |
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1: MKYLFFSLFL CYNLIVYIYC VSKNAYNIKE KRRGECNFPI NNQRCNNNMN SLIMNKYLYK
61: KRKHSNTLPF IKTYNNFKEK NKNDVVQISY YSINHNKKYN NKIHTHILFM NNNNNNNNNS
121: NSNKEYIKAN NANMLFSIYN KISEDGKTKN SLLSDISKLF KIVKESKLIF VTGFLLTTLS
181: AIVDSYIPIF LSKTVSFVME RKKFTFLKIH KTNLSVVKNL IEYLKFYSTN PFHMYVLISV
241: ISLLFSSFRS YIFNVCAYVS TNKLQKYLFN VLLHKNINYF KKKGKGELIS RLNIDSSELI
301: DIFTTNIIVL FRNMIKMALS FYFLYKINVH LFIVSLFIVF IISNISIFFS NIFRKLAKEE
361: SNVVAQSNNI VEESIYNFSL ISTFNTHNKE IKKYNNSLDT IYMSRMKLGL LYIIEKFFIR
421: LIDMMTFILT LILSKKTLMY NLNTDTRTII SSVIYMQNII AQSCIIEQQY SRVQELIGNA
481: EEVIKLIEKD NMRNNNNNNN NDNIKLVSNK YNFFSILFNI NDMKNFIFNH SLLKKFQTIQ
541: NNSDYVFNII KPNYLKLFER NYNNLIKLFF NEKNFNQCDE SLFKNGSIDD INNIDMYEKK
601: EETNKINDYH NFISNKQMYD NKTKDCTLKK KKQDNSFYYN TPNNNVEMKN QLDQHSFSKS
661: ENFQNKLKKK IQEINMQEVY QFIKNDHALI IKYKLDRKFI RFLKTNYKKN IILLILKLYK
721: ERNNSVSDNF LFLFDNISSF KNLSIKDKKS ILKMSNITNK TIYIILLTFL FYNYSKFYYK
781: KQKKKNFINF IEKKNKMLKN NQNVERGQHG SSTYEKMYES MDDEININDV LSDAISDTIC
841: DNSNDTIRDN SNDTICDNSN NTICDNSNDT ICDNSNVISS NYQSNQHLYP QIMSTTPNKN
901: DQYNNPTDNL ELNNESVILN KTKSRTKKKR NLYNILPYIV ENAIKELEIL KFIDANYKSI
961: NENLILDNIK DNQKGSTLIF ENVDFYFAKY PKNKILSNIN LNFSNKYTYG ILCYNDSGKN
1021: YLAKLAARLY NKTYGNILLD DENIENISKY ILTKKISLVE EQSYIFSDSI IYNMLYSYNC
1081: ITKGNKNFYY LNYNFKLNKN NINNCVHLFS HDNDITTNDY NNNNINKNIN SDNYSSSSSS
1141: NTISSCRNYE QYEKIKEKNK KPKIKYKIKE NKPSIYNIHN TTNNNTVDQS LYTFKNFKKK
1201: CLMCGSLIDT KLLEEQKKSP NYNKYKVHFI KKLYKEIIKV SKIVCLYDVI NSYPDKFFHN
1261: INDKILSGGQ KQKISLARAI IKKPKILILD DAFSALDAAN ELKIFSSLKN YLPNCTIVNL
1321: SHKITTVNKC DYIYVLKDGK IIEHGLRTKL IQNRNSEYIK KFNEY