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3.A.1.201.50
The human ABCB5 exists in two forms (812 aas and 1257 aas). The latter full length protein confers resistance to taxanes and anthracyclines (Kawanobe et al., 2012). Resistance and transport were demonstrated for paclitaxel and docetaxel as well. It is present in a number of stem cells that acts as a regulator of cellular differentiation. It is able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin (Frank et al. 2005; Huang et al. 2004). It is specifically present in limbal stem cells, where it plays a key role in corneal development and repair (Frank et al. 2003).

Accession Number:Q2M3G0
Protein Name:ATP-binding cassette sub-family B member 5
Length:812
Molecular Weight:89832.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

Entrez Gene ID: 340273   
Pfam: PF00664    PF00005   
KEGG: hsa:340273   

Gene Ontology

GO:0016324 C:apical plasma membrane
GO:0000139 C:Golgi membrane
GO:0005887 C:integral to plasma membrane
GO:0046581 C:intercellular canaliculus
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane movement of substances
GO:0015562 F:efflux transmembrane transporter activity
GO:0042391 P:regulation of membrane potential

References (8)

[1] “Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter.”  Frank N.Y.et.al.   12960149
[2] “Principal expression of two mRNA isoforms (ABCB 5alpha and ABCB 5beta) of the ATP-binding cassette transporter gene ABCB 5 in melanoma cells and melanocytes.”  Chen K.G.et.al.   15760339
[3] “Human chromosome 7: DNA sequence and biology.”  Scherer S.W.et.al.   12690205
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Membrane transporters and channels: role of the transportome in cancer chemosensitivity and chemoresistance.”  Huang Y.et.al.   15205344
[6] “ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma.”  Frank N.Y.et.al.   15899824
[7] “The consensus coding sequences of human breast and colorectal cancers.”  Sjoeblom T.et.al.   16959974
[8] “Core signaling pathways in human pancreatic cancers revealed by global genomic analyses.”  Jones S.et.al.   18772397

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MVDENDIRAL NVRHYRDHIG VVSQEPVLFG TTISNNIKYG RDDVTDEEME RAAREANAYD 
61:	FIMEFPNKFN TLVGEKGAQM SGGQKQRIAI ARALVRNPKI LILDEATSAL DSESKSAVQA 
121:	ALEKASKGRT TIVVAHRLST IRSADLIVTL KDGMLAEKGA HAELMAKRGL YYSLVMSQDI 
181:	KKADEQMESM TYSTERKTNS LPLHSVKSIK SDFIDKAEES TQSKEISLPE VSLLKILKLN 
241:	KPEWPFVVLG TLASVLNGTV HPVFSIIFAK IITMFGNNDK TTLKHDAEIY SMIFVILGVI 
301:	CFVSYFMQGL FYGRAGEILT MRLRHLAFKA MLYQDIAWFD EKENSTGGLT TILAIDIAQI 
361:	QGATGSRIGV LTQNATNMGL SVIISFIYGW EMTFLILSIA PVLAVTGMIE TAAMTGFANK 
421:	DKQELKHAGK IATEALENIR TIVSLTREKA FEQMYEEMLQ TQHRNTSKKA QIIGSCYAFS 
481:	HAFIYFAYAA GFRFGAYLIQ AGRMTPEGMF IVFTAIAYGA MAIGETLVLA PEYSKAKSGA 
541:	AHLFALLEKK PNIDSRSQEG KKPDTCEGNL EFREVSFFYP CRPDVFILRG LSLSIERGKT 
601:	VAFVGSSGCG KSTSVQLLQR LYDPVQGQVL FDGVDAKELN VQWLRSQIAI VPQEPVLFNC 
661:	SIAENIAYGD NSRVVPLDEI KEAANAANIH SFIEGLPEKY NTQVGLKGAQ LSGGQKQRLA 
721:	IARALLQKPK ILLLDEATSA LDNDSEKVVQ HALDKARTGR TCLVVTHRLS AIQNADLIVV 
781:	LHNGKIKEQG THQELLRNRD IYFKLVNAQS VQ