3.A.1.204.20
ATP-binding cassette sub-family G member 4, ABCG4, half transporter of 646 aas. ABCG4 can form homodimers, but also
heterodimers with its closest relative, ABCG1. Both the full-length and the short isoforms of ABCG1
can dimerize with ABCG4, whereas the ABCG2 multidrug transporter is unable to form a heterodimer
with ABCG4 (Hegyi and Homolya 2016). ABCG4 is
predominantly localized to the plasma membrane. AbcG4 acts in concert with ABCA1, ABCB1 and ABCG2 to efflux amyloid-β
peptide (Aβ) from the brain across the blood-brain barrier (BBB) (Kuai et al. 2018). It is involved in macrophage lipid homeostasis (Sakamoto et al. 2019).
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| Accession Number: | Q9H172 |
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| Protein Name: | ATP-binding cassette sub-family G member 4 |
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| Length: | 646 |
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| Molecular Weight: | 71896.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 8 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
amyloid-beta |
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1: MAEKALEAVG CGLGPGAVAM AVTLEDGAEP PVLTTHLKKV ENHITEAQRF SHLPKRSAVD
61: IEFVELSYSV REGPCWRKRG YKTLLKCLSG KFCRRELIGI MGPSGAGKST FMNILAGYRE
121: SGMKGQILVN GRPRELRTFR KMSCYIMQDD MLLPHLTVLE AMMVSANLKL SEKQEVKKEL
181: VTEILTALGL MSCSHTRTAL LSGGQRKRLA IALELVNNPP VMFFDEPTSG LDSASCFQVV
241: SLMKSLAQGG RTIICTIHQP SAKLFEMFDK LYILSQGQCI FKGVVTNLIP YLKGLGLHCP
301: TYHNPADFII EVASGEYGDL NPMLFRAVQN GLCAMAEKKS SPEKNEVPAP CPPCPPEVDP
361: IESHTFATST LTQFCILFKR TFLSILRDTV LTHLRFMSHV VIGVLIGLLY LHIGDDASKV
421: FNNTGCLFFS MLFLMFAALM PTVLTFPLEM AVFMREHLNY WYSLKAYYLA KTMADVPFQV
481: VCPVVYCSIV YWMTGQPAET SRFLLFSALA TATALVAQSL GLLIGAASNS LQVATFVGPV
541: TAIPVLLFSG FFVSFKTIPT YLQWSSYLSY VRYGFEGVIL TIYGMERGDL TCLEERCPFR
601: EPQSILRALD VEDAKLYMDF LVLGIFFLAL RLLAYLVLRY RVKSER