3.A.3.10.2
Zebrafish ATP13A2 (Parkinson''s disease protein) is essential for embryonic survival (Lopes da Fonseca et al. 2013). A missense variant in Australian Cattle Dogs give rise to late onset neuronal ceroid lipofuscinosis (Schmutz et al. 2019).
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| Accession Number: | Q7SXR0 |
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| Protein Name: | ATPase type 13A |
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| Length: | 1177 |
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| Molecular Weight: | 131130.00 |
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| Species: | Danio rerio (Zebrafish) [7955] |
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| Number of TMSs: | 12 |
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| Substrate |
cation |
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1: MAADGVDGPA GTRTRAPSDD LVRAVSLHSR RPRVLHGTVF PFLILYPACL YTWFGVYGAA
61: EYVEAGLLAL AALGIAHVLT VLSGYWSVHA HCLLTCSKES DPAKATFAKV IPTPNNGSAE
121: LVPLLRDKDE DGAEILSFEF QKICYVYDGE EKKQFLPVAF PISFPMSHFQ NWRGYQEEVQ
181: LRAAEKRYGT NRAEMVVPDF LELFKERATA PFFVFQVFCV GLWCLDEYWY YSVFTLFMLV
241: AFEASLVQQQ MRNMSEIRRM GNKPYMIQVY RNRKWRPISS DELVPGDIVS VGRSPQDNLV
301: PCDVLLLRGR CIVDEAMLTG GSVPQMKEPI EDLDPNRILD LQTDSRLHII SGGTKVVQHS
361: PPLRASAGLK PVDNGCVAYV LRTGFYTSQG KLLRTILFGV KRVTANNLET FIFILFLLVF
421: AIAAAVYVWV EGTKDPSRNK YKLFLECTLI LTSVVPPELP IELSLAVNTS LIALAKLYVF
481: CTEPFRIPFA GKVEICCFDK TGTLTSDSLV VRGVAGLREG KQVMPVSEIP VDTHRVVATC
541: HSLVTLDDGQ LVGDPLEKAM LTAADWTLTK DEKVFARSTK TPGLKIHQRF HFTSALKRMS
601: VLASYERMGS TELCYISTVK GAPETLRNMF SECPASYDEV HREMSREGAR VLALGYKEMG
661: HLSHQQVREV SREQLECDLR FAGFMVVSCP LKSDSKAVIR EIQEASHHVV MITGDNPLTA
721: CHVARELHFI QKEHTLILQQ SSSQAEWQWV SIDGSVSLPL PPSSVSELIQ RYDLCVTGEG
781: LARLKFDPQL LSALLPHVRV FARVSPKQKE FVITSLKGLG FVTLMCGDGT NDVGALKHAH
841: IGVALLANAP ERMPEKKKRN KEKEYSSGES RPGPPVPTSG GKLSSRAARQ RLMAQREEQL
901: AAQKERISQV LRELEEDQIQ VAKLGDASIA APFTSKLSSI QCICHVIKQG RCTLVTTLQM
961: FKILALNALI LAYSQSVLYL EGVKFSDFQA TLQGLLLAGC FLFISRSKPL KSLSKERPLP
1021: NIFNLYTVLT VLLQFAVHFC SLVYLYKGAQ TRSPPRSEQF VDLYKEFEPS LINSTVYIMS
1081: MAMQMATFAI NYKGHPFMES LTENRPLLWS IAISGLAIVG LLTGSSPEFN EQFALVDIPT
1141: EFKLIIAQVL VVDFVAALLV DRVLQFLLGK GTLRLPK