3.A.3.10.22
Manganese transporter of 1179 aas and 12 probable TMSs (Ticconi et al. 2004). Mediates manganese transport into the
endoplasmic reticulum. The ATPase activity is required for cellular
manganese homeostasis. Plays an important role in pollen
and root development through its impact on protein secretion and
transport processes (Jakobsen et al. 2005). Functions together with LPR1 and LPR2 in a common
pathway that adjusts root meristem activity to phosphate availability (Ticconi et al. 2009).
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| Accession Number: | Q9LT02 |
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| Protein Name: | Probable manganese-transporting ATPase PDR2 |
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| Length: | 1179 |
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| Molecular Weight: | 131115.00 |
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| Species: | Arabidopsis thaliana (Mouse-ear cress) [3702] |
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| Number of TMSs: | 12 |
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| Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum membrane1 / Multi-pass membrane protein2 |
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| Substrate |
manganese(2+) |
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1: MSSFRVGGKV VEKVDLCRKK QLVWRLDVWP FAILYTVWLT TIVPSIDFSD ACIALGGLSA
61: FHILVLLFTT WSVDFKCFVQ FSKVNSIDQA DACKVTPAKF SGSKEVVPLH FRSQMTDSAS
121: SGDMEEIFFD FRKQRFIYSK ELGAFSKLPY PTKETFGHYL KCTGHGTEAK IATATEKWGR
181: NVFDYPQPTF QKLMKENCME PFFVFQVFCV GLWCLDEFWY YSVFTLFMLF MFESTMAKSR
241: LKTLTDLRSV RVDSQTVMVY RSGKWVKLLG TDLLPGDVVS IGRPSTQTGG EDKTVPADML
301: LLVGSAIVNE AILTGESTPQ WKVPIVGQRS DEKLSIKRNK NHVLFGGTKI LQHSPDKSFS
361: LKTPDGGCLA VVLRTGFETS QGKLMRTILF STERVTANSW ESGLFILFLV VFAVIAAGYV
421: LVKGLEDPTR SKYKLLLGCS LIITSVIPPE LPMELSIAVN TSLLALVRRG IFCTEPFRIP
481: FAGKVDLCCF DKTGTLTSDD MEFRGVGGLS NCEEAETDMS KVPVRTLEIL ASCHALVFVE
541: NKLVGDPLEK AALKGIDWSY KADEKALPRR GNGNSVQIMQ RYHFASHLKR MSVIVRIQEE
601: YLAFVKGAPE TIQERLVDVP AQYIETYKRY TRQGSRVLAL AYKRLPDMMV SEARDMDRDA
661: VESDLTFAGF AVFNCPIRPD SAPVLLELKN SSHDLVMITG DQALTACHVA GQVHIVSNPV
721: LILGRSGSGN EYKWVSPDEK EIIPYSEKEI ETLAETHDLC IGGDSIEMLQ ATSAVLRVIP
781: FVKVFARVAP QQKELILTTF KAVGRGTLMC GDGTNDVGAL KQAHVGVALL NNKLPLSPSD
841: SSKDDKSKSK KSKLPLEPAS KTITQNGEGS SKGKIPPQNR HLTAAELQRQ KLKKIMDDLN
901: NDEGDGRSAP LVKLGDASMA SPFTAKHASV APVTDIIRQG RSTLVTTLQM FKILGLNCLA
961: TAYVLSVMYL DGVKLGDVQA TISGVLTAAF FLFISHARPL QTLSAERPHP SVFSVYLFLS
1021: LIGQFAVHLT FLVYSVKEAE KHMPEECIEP DASFHPNLVN TVSYMVSMML QVATFAVNYM
1081: GHPFNQSIRE NKPFFYALIA GAGFFTVIAS DLFRDLNDSL KLVPLPQGLR DKLLIWASLM
1141: FIICYSWERL LRWAFPGKIS SWKHKQRAVT ANLEKKKKV