3.A.3.2.53 CtpF, a probable Ca2+ ATPase of 905 aas and 10 TMSs in a 2 + 2 + 6 TMS arrangement. Specific targeting to the Mycobacterium tuberculosis P-type ATPase membrane transporter, CtpF, by antituberculous compounds obtained by structure-based design, has been demonstrated (Santos et al. 2023).
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Accession Number: | P9WPS8 |
Protein Name: | Probable cation-transporting ATPase F |
Length: | 905 |
Molecular Weight: | 95033.00 |
Species: | Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) [83331] |
Number of TMSs: | 10 |
Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
Substrate |
calcium ion |
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1: MSASVSATTA HHGLPAHEVV LLLESDPYHG LSDGEAAQRL ERFGPNTLAV VTRASLLARI
61: LRQFHHPLIY VLLVAGTITA GLKEFVDAAV IFGVVVINAI VGFIQESKAE AALQGLRSMV
121: HTHAKVVREG HEHTMPSEEL VPGDLVLLAA GDKVPADLRL VRQTGLSVNE SALTGESTPV
181: HKDEVALPEG TPVADRRNIA YSGTLVTAGH GAGIVVATGA ETELGEIHRL VGAAEVVATP
241: LTAKLAWFSK FLTIAILGLA ALTFGVGLLR RQDAVETFTA AIALAVGAIP EGLPTAVTIT
301: LAIGMARMAK RRAVIRRLPA VETLGSTTVI CADKTGTLTE NQMTVQSIWT PHGEIRATGT
361: GYAPDVLLCD TDDAPVPVNA NAALRWSLLA GACSNDAALV RDGTRWQIVG DPTEGAMLVV
421: AAKAGFNPER LATTLPQVAA IPFSSERQYM ATLHRDGTDH VVLAKGAVER MLDLCGTEMG
481: ADGALRPLDR ATVLRATEML TSRGLRVLAT GMGAGAGTPD DFDENVIPGS LALTGLQAMS
541: DPPRAAAASA VAACHSAGIA VKMITGDHAG TATAIATEVG LLDNTEPAAG SVLTGAELAA
601: LSADQYPEAV DTASVFARVS PEQKLRLVQA LQARGHVVAM TGDGVNDAPA LRQANIGVAM
661: GRGGTEVAKD AADMVLTDDD FATIEAAVEE GRGVFDNLTK FITWTLPTNL GEGLVILAAI
721: AVGVALPILP TQILWINMTT AIALGLMLAF EPKEAGIMTR PPRDPDQPLL TGWLVRRTLL
781: VSTLLVASAW WLFAWELDNG AGLHEARTAA LNLFVVVEAF YLFSCRSLTR SAWRLGMFAN
841: RWIILGVSAQ AIAQFAITYL PAMNMVFDTA PIDIGVWVRI FAVATAITIV VATDTLLPRI
901: RAQPP