3.A.3.3.12
ATPase-7, AHA7, of 961 aas and 10 TMSs. 73% identical to AHA2 with which it shares function. AHA7 is autoinhibited by a sequence present in the extracellular loop between transmembrane segments 7 and 8. Autoinhibition of pump activity is regulated by extracellular pH, suggesting negative feedback regulation of AHA7 during establishment of an H+ gradient. Restriction of root hair elongation is dependent on both AHA2 and AHA7, with each having different roles in this process (Hoffmann et al. 2018).
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| Accession Number: | Q9LY32 |
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| Protein Name: | ATPase 7, plasma membrane-type |
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| Length: | 961 |
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| Molecular Weight: | 105520.00 |
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| Species: | Arabidopsis thaliana (Mouse-ear cress) [3702] |
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| Number of TMSs: | 10 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
proton |
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1: MTDIEALKAI TTESIDLENV PVEEVFQHLK CTKEGLTSNE VQERLTLFGY NKLEEKKESK
61: ILKFLGFMWN PLSWVMEAAA LMAIGLAHGG GKPADYHDFV GIVVLLLINS TISFVEENNA
121: GNAAAALMAQ LAPKAKAVRD GKWNEIDAAE LVPGDIVSIK LGDIIPADAR LLEGDPLKID
181: QATLTGESLP VTKNPGASVY SGSTCKQGEI EAVVIATGVH TFFGKAAHLV DSTTHVGHFQ
241: KVLTAIGNFC ICSIAVGMAI EIVVIYGLQK RGYRVGIDNL LVLLIGGIPI AMPTVLSVTM
301: AIGAHRLAQQ GAITKRMTAI EEMAGMDVLC SDKTGTLTLN KLSVDKNLIE VFKRGIDRDM
361: AVLMAARAAR LENQDAIDTA IVSMLSDPKE ARAGIKELHF LPFSPANRRT ALTYLDGEGK
421: MHRVSKGAPE EILDMAHNKL EIKEKVHATI DKFAERGLRS LGLAYQEVPD GDVKGEGGPW
481: DFVALLPLFD PPRHDSAQTI ERALHLGVSV KMITGDQLAI AKETGRRLGM GTNMYPSSSL
541: LSDNNTEGVS VDELIENADG FAGVFPEHKY EIVKRLQSRK HICGMTGDGV NDAPALKKAD
601: IGIAVDDATD AARGASDIVL TEPGLSVIIS AVLTSRAIFQ RMKNYTIYAV SITIRIVMGF
661: MLLCVFWEFD FPPFMVLVIA ILNDGTIMTI SKDRVKPSPT PDCWKLKEIF ATGVVLGAYL
721: AIMTVVFFWA AYETNFFHNI FHVRNFNQHH FKMKDKKVAA HLNEQMASAV YLQVSTISQA
781: LIFVTRSRSW SFVERPGFLL VIAFLIAQLV ASVISAMANW PFAGIRSIGW GWTGVIWIFN
841: IVTYMLLDPI KFLVRYALSG KSWDRMVEGR TALTGKKNFG QEERMAAWAT EKRTQHGLET
901: GQKPVYERNS ATELNNMAEE AKRRAEIARM RELQTLKGKV ESAAKLKGYD LEDPNSNNYT
961: I