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| Accession Number: | O32220 |
| Protein Name: | Copper-transporting P-type ATPase aka CopA |
| Length: | 802 |
| Molecular Weight: | 85912.00 |
| Species: | Bacillus subtilis [1423] |
| Number of TMSs: | 8 |
| Location1 / Topology2 / Orientation3: | Cell membrane1 / Multi-pass membrane protein2 |
| Substrate | copper(1+) |
Cross database links:
| RefSeq: | NP_391230.2 |
|---|---|
| Entrez Gene ID: | 937985 |
| Pfam: | PF00122 PF00403 PF00702 |
| KEGG: | bsu:BSU33500 |
Gene Ontology
GO:0016021
C:integral to membrane
GO:0005886
C:plasma membrane
GO:0005524
F:ATP binding
GO:0005507
F:copper ion binding
GO:0004008
F:copper-exporting ATPase activity
GO:0006754
P:ATP biosynthetic process
GO:0006825
P:copper ion transport
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References (7)[1] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.” Kunst F.et.al. 9384377 [2] “CopZ from Bacillus subtilis interacts in vivo with a copper exporting CPx-type ATPase CopA.” Radford D.S.et.al. 12644235 [3] “Two MerR homologues that affect copper induction of the Bacillus subtilis copZA operon.” Gaballa A.et.al. 14663075 [4] “Solution structure of the N-terminal domain of a potential copper-translocating P-type ATPase from Bacillus subtilis in the apo and Cu(I) loaded states.” Banci L.et.al. 11922674 [5] “Structural basis for the function of the N-terminal domain of the ATPase CopA from Bacillus subtilis.” Banci L.et.al. 14514665 [6] “Understanding copper trafficking in bacteria: interaction between the copper transport protein CopZ and the N-terminal domain of the copper ATPase CopA from Bacillus subtilis.” Banci L.et.al. 12590580 [7] “Structure and Cu(I)-binding properties of the N-terminal soluble domains of Bacillus subtilis CopA.” Singleton C.et.al. 18215122
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| Structure: | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MSEQKEIAMQ VSGMTCAACA ARIEKGLKRM PGVTDANVNL ATETSNVIYD PAETGTAAIQ 61: EKIEKLGYHV VTEKAEFDIE GMTCAACANR IEKRLNKIEG VANAPVNFAL ETVTVEYNPK 121: EASVSDLKEA VDKLGYKLKL KGEQDSEAAA KKKEERKQTA RLIFSAVLSF PLLWAMVSHF 181: TFTSFIWVPD IFLNPWMQFA LATPVQFLIG WPFYVGAYKA LRNKSANMDV LVALGTTAAY 241: AYSLYLTFQS IGSHGHTDGL YYETSAILLT LILLGKLFET KAKGRSSDAI KKLMKLQAKT 301: ATVVRDGQEQ IIPIDEVLVN DIVYVKPGER IPVDGEVVEG RSAVDESMIT GESLPVDKNP 361: GDSVTGSTVN ANGFLKIKAV NVGKDTALSH IIKIVEEAQG SKAPIQRLAD QISGIFVPIV 421: LGIAVLTFLI WYLWAAPGDF AEAISKFIAV LVIACPCALG LATPTSIMAG SGRAAEFGIL 481: FKGGEHLEKT HRLDTIVLDK TGTVTNGKPR LTDAIPFGRF EEKDLLQFAA AAETGSEHPL 541: GEAIIAGVKD KGLEIPKLTR FEAKVGAGIL AEAGGKSILV GTRKLMESEQ VEHGALLAQM 601: EELEAEGKTV MLVSIDGEAA GLVAVADTIK DTSRKAVARL KELGLDVIMM TGDNRRTAEA 661: IAKEAGIANI IAEVLPEQKA AEIARLQKEG RQTAMVGDGI NDAPALATAD IGMAIGTGTD 721: IAMETADITL IRGDLNSIAD AIRMSRLTMK NIKQNLFWAL GYNSLGIPIA ALGFLAPWIA 781: GAAMAFSSVS VVLNALRLQK VK