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3.A.3.5.32
Copper-transporting ATPase RAN1 or HMP7 (EC 3.6.3.4) (Protein HEAVY METAL ATPASE 7) (Protein RESPONSIVE TO ANTAGONIST 1). Receptors involved in ethylene signaling can acquire their copper load by different routes and adopt the metal ion from the plasma membrane either by sequential transfer from soluble chaperones of the ATX1-family via the ER-bound copper-transporting ATPase RAN1 or by direct transfer from the soluble chaperones (Hoppen and Groth 2020). ER-anchored SPL7 (Transcription factor) constitutes a cellular mechanism for the regulation of RAN1 in ethylene signaling and lays the foundation for investigating how Cu homeostatic conditions ethylene sensitivity in the developmental context (Yang et al. 2022).  

Accession Number:Q9S7J8
Protein Name:Copper-transporting ATPase RAN1
Length:1001
Molecular Weight:107395.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate copper(1+)

Cross database links:

Entrez Gene ID: 834509   
Pfam: PF00122    PF00403    PF00702   
KEGG: ath:AT5G44790   

Gene Ontology

GO:0005794 C:Golgi apparatus
GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0005507 F:copper ion binding
GO:0005375 F:copper ion transmembrane transporter activity
GO:0004008 F:copper-exporting ATPase activity
GO:0006754 P:ATP biosynthetic process
GO:0060003 P:copper ion export
GO:0009873 P:ethylene mediated signaling pathway
GO:0010119 P:regulation of stomatal movement

References (3)

[1] “Responsive-to-antagonist 1, a Menkes/Wilson disease-related copper transporter, is required for ethylene signaling in Arabidopsis.”  Hirayama T.et.al.   10319818
[2] “Structural analysis of Arabidopsis thaliana chromosome 5. VIII. Sequence features of the regions of 1,081,958 bp covered by seventeen physically assigned P1 and TAC clones.”  Asamizu E.et.al.   10048488
[3] “Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.”  Tabata S.et.al.   11130714
Structure:
3DXS     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MAPSRRDLQL TPVTGGSSSQ ISDMEEVGLL DSYHNEANAD DILTKIEEGR DVSGLRKIQV 
61:	GVTGMTCAAC SNSVEAALMN VNGVFKASVA LLQNRADVVF DPNLVKEEDI KEAIEDAGFE 
121:	AEILAEEQTQ ATLVGQFTIG GMTCAACVNS VEGILRDLPG VKRAVVALST SLGEVEYDPN 
181:	VINKDDIVNA IEDAGFEGSL VQSNQQDKLV LRVDGILNEL DAQVLEGILT RLNGVRQFRL 
241:	DRISGELEVV FDPEVVSSRS LVDGIEEDGF GKFKLRVMSP YERLSSKDTG EASNMFRRFI 
301:	SSLVLSIPLF FIQVICPHIA LFDALLVWRC GPFMMGDWLK WALVSVIQFV IGKRFYVAAW 
361:	RALRNGSTNM DVLVALGTSA SYFYSVGALL YGAVTGFWSP TYFDASAMLI TFVLLGKYLE 
421:	SLAKGKTSDA MKKLVQLTPA TAILLTEGKG GKLVGEREID ALLIQPGDTL KVHPGAKIPA 
481:	DGVVVWGSSY VNESMVTGES VPVSKEVDSP VIGGTINMHG ALHMKATKVG SDAVLSQIIS 
541:	LVETAQMSKA PIQKFADYVA SIFVPVVITL ALFTLVGWSI GGAVGAYPDE WLPENGTHFV 
601:	FSLMFSISVV VIACPCALGL ATPTAVMVAT GVGATNGVLI KGGDALEKAH KVKYVIFDKT 
661:	GTLTQGKATV TTTKVFSEMD RGEFLTLVAS AEASSEHPLA KAIVAYARHF HFFDESTEDG 
721:	ETNNKDLQNS GWLLDTSDFS ALPGKGIQCL VNEKMILVGN RKLMSENAIN IPDHVEKFVE 
781:	DLEESGKTGV IVAYNGKLVG VMGIADPLKR EAALVVEGLL RMGVRPIMVT GDNWRTARAV 
841:	AKEVGIEDVR AEVMPAGKAD VIRSLQKDGS TVAMVGDGIN DSPALAAADV GMAIGAGTDV 
901:	AIEAADYVLM RNNLEDVITA IDLSRKTLTR IRLNYVFAMA YNVVSIPIAA GVFFPVLRVQ 
961:	LPPWAAGACM ALSSVSVVCS SLLLRRYKKP RLTTVLKITT E