3.A.3.5.41
Cuprous ion (Cu+) exporter, CtpA (does not export Co2+, Mn2+, Ni2+, Zn2+ or Cu2+). Km for Cu+ = 0.05 μM (León-Torres et al. 2015).
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| Accession Number: | P9WPU1 |
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| Protein Name: | Copper-exporting P-type ATPase |
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| Length: | 761 |
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| Molecular Weight: | 78851.00 |
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| Species: | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [83332] |
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| Number of TMSs: | 8 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
copper(1+) |
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1: MTTAVTGEHH ASVQRIQLRI SGMSCSACAH RVESTLNKLP GVRAAVNFGT RVATIDTSEA
61: VDAAALCQAV RRAGYQADLC TDDGRSASDP DADHARQLLI RLAIAAVLFV PVADLSVMFG
121: VVPATRFTGW QWVLSALALP VVTWAAWPFH RVAMRNARHH AASMETLISV GITAATIWSL
181: YTVFGNHSPI ERSGIWQALL GSDAIYFEVA AGVTVFVLVG RYFEARAKSQ AGSALRALAA
241: LSAKEVAVLL PDGSEMVIPA DELKEQQRFV VRPGQIVAAD GLAVDGSAAV DMSAMTGEAK
301: PTRVRPGGQV IGGTTVLDGR LIVEAAAVGA DTQFAGMVRL VEQAQAQKAD AQRLADRISS
361: VFVPAVLVIA ALTAAGWLIA GGQPDRAVSA ALAVLVIACP CALGLATPTA MMVASGRGAQ
421: LGIFLKGYKS LEATRAVDTV VFDKTGTLTT GRLQVSAVTA APGWEADQVL ALAATVEAAS
481: EHSVALAIAA ATTRRDAVTD FRAIPGRGVS GTVSGRAVRV GKPSWIGSSS CHPNMRAARR
541: HAESLGETAV FVEVDGEPCG VIAVADAVKD SARDAVAALA DRGLRTMLLT GDNPESAAAV
601: ATRVGIDEVI ADILPEGKVD VIEQLRDRGH VVAMVGDGIN DGPALARADL GMAIGRGTDV
661: AIGAADIILV RDHLDVVPLA LDLARATMRT VKLNMVWAFG YNIAAIPVAA AGLLNPLVAG
721: AAMAFSSFFV VSNSLRLRKF GRYPLGCGTV GGPQMTAPSS A