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3.A.3.6.6 Chloroplast envelope Cu⁺-ATPase, HMA1 (Seigneurin-Berny et al., 2006). Transports many heavy metals (Zn²⁺, Cu²⁺, Cd²⁺, Co²⁺), increasing heavy metal tolerance. Also transports Ca²⁺ (Km=370nM) in a thapsigargin-sensitive fashion (Moreno et al, 2008).
Accession Number:	Q9M3H5
Protein Name:	Hma1
Length:	819
Molecular Weight:	88189.00
Species:	Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:	7
Location¹ / Topology² / Orientation³:	Plastid¹ / Multi-pass membrane protein²
Substrate	cadmium(2+), calcium(2+), cobalt(2+), copper(2+), zinc(2+)

RefSeq:	NP_195444.1
Entrez Gene ID:	829881
Pfam:	PF00122 PF00702
KEGG:	ath:AT4G37270
Gene Ontology GO:0009706 C:chloroplast inner membrane GO:0016021 C:integral to membrane GO:0005524 F:ATP binding GO:0008551 F:cadmium-exporting ATPase activity GO:0015434 F:cadmium-transporting ATPase activity GO:0005388 F:calcium-transporting ATPase activity GO:0046872 F:metal ion binding GO:0015633 F:zinc transporting ATPase activity GO:0016463 F:zinc-exporting ATPase activity GO:0006754 P:ATP biosynthetic process GO:0006816 P:calcium ion transport GO:0006878 P:cellular copper ion homeostasis GO:0009642 P:response to light intensity GO:0009636 P:response to toxin GO:0055069 P:zinc ion homeostasis
References (2) [1] “Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.” Mayer K.F.X.et.al. 10617198 [2] “Proteomics of the chloroplast envelope membranes from Arabidopsis thaliana.” Ferro M.et.al. 12766230

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MEPATLTRSS SLTRFPYRRG LSTLRLARVN SFSILPPKTL LRQKPLRISA SLNLPPRSIR 
61:	LRAVEDHHHD HHHDDEQDHH NHHHHHHQHG CCSVELKAES KPQKMLFGFA KAIGWVRLAN 
121:	YLREHLHLCC SAAAMFLAAA VCPYLAPEPY IKSLQNAFMI VGFPLVGVSA SLDALMDIAG 
181:	GKVNIHVLMA LAAFASVFMG NALEGGLLLA MFNLAHIAEE FFTSRSMVDV KELKESNPDS 
241:	ALLIEVHNGN VPNISDLSYK SVPVHSVEVG SYVLVGTGEI VPVDCEVYQG SATITIEHLT 
301:	GEVKPLEAKA GDRVPGGARN LDGRMIVKAT KAWNDSTLNK IVQLTEEAHS NKPKLQRWLD 
361:	EFGENYSKVV VVLSLAIAFL GPFLFKWPFL STAACRGSVY RALGLMVAAS PCALAVAPLA 
421:	YATAISSCAR KGILLKGAQV LDALASCHTI AFDKTGTLTT GGLTCKAIEP IYGHQGGTNS 
481:	SVITCCIPNC EKEALAVAAA MEKGTTHPIG RAVVDHSVGK DLPSIFVESF EYFPGRGLTA 
541:	TVNGVKTVAE ESRLRKASLG SIEFITSLFK SEDESKQIKD AVNASSYGKD FVHAALSVDQ 
601:	KVTLIHLEDQ PRPGVSGVIA ELKSWARLRV MMLTGDHDSS AWRVANAVGI TEVYCNLKPE 
661:	DKLNHVKNIA REAGGGLIMV GEGINDAPAL AAATVGIVLA QRASATAIAV ADILLLRDNI 
721:	TGVPFCVAKS RQTTSLVKQN VALALTSIFL AALPSVLGFV PLWLTVLLHE GGTLLVCLNS 
781:	VRGLNDPSWS WKQDIVHLIN KLRSQEPTSS SSNSLSSAH

3.A.3.6.6
Chloroplast envelope Cu⁺-ATPase, HMA1 (Seigneurin-Berny et al., 2006). Transports many heavy metals (Zn²⁺, Cu²⁺, Cd²⁺, Co²⁺), increasing heavy metal tolerance. Also transports Ca²⁺ (Km=370nM) in a thapsigargin-sensitive fashion (Moreno et al, 2008).

Cross database links:

Gene Ontology

References (2)

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3.A.3.6.6Chloroplast envelope Cu+-ATPase, HMA1 (Seigneurin-Berny et al., 2006). Transports many heavy metals (Zn2+, Cu2+, Cd2+, Co2+), increasing heavy metal tolerance. Also transports Ca2+ (Km=370nM) in a thapsigargin-sensitive fashion (Moreno et al, 2008).

Cross database links:

Gene Ontology

References (2)

External Searches:

Analyze:

3.A.3.6.6
Chloroplast envelope Cu⁺-ATPase, HMA1 (Seigneurin-Berny et al., 2006). Transports many heavy metals (Zn²⁺, Cu²⁺, Cd²⁺, Co²⁺), increasing heavy metal tolerance. Also transports Ca²⁺ (Km=370nM) in a thapsigargin-sensitive fashion (Moreno et al, 2008).