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3.A.3.8.1
Golgi Aminophospholipid (phosphatidyl serine and phosphatidyl ethanolamine) translocase (flipping from the exofacial to the cytosolic leaflet of membranes to generate phospholipid asymmetry), required for vesicle-mediated protein transport from the Golgi and endosomes. The system has been reconstituted after purification in proteoliposomes. It flips phosphatidyl serine but not phosphatidylcholine or sphinogomyelin (Zhou and Graham, 2009).  A unified mechanism of flipping for ABC and P-type ATPases has been proposed (López-Marqués et al. 2014).  Several high-resolution structures of human or yeast P4-ATPases have recently been resolved. Sai and Lee 2024 have compiled available data reflecting the reaction cycle-associated changes in conformation of P4-ATPases.

Accession Number:Q29449
Protein Name:AT1A aka ATP8A1
Length:1149
Molecular Weight:130026.00
Species:Bos taurus (Bovine) [9913]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cytoplasmic vesicle1 / Multi-pass membrane protein2
Substrate aminophospholipid

Cross database links:

RefSeq: NP_777263.1   
Entrez Gene ID: 317692   
Pfam: PF00122    PF00702   
KEGG: bta:317692   

Gene Ontology

GO:0042584 C:chromaffin granule membrane
GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0015662 F:ATPase activity, coupled to transmembrane m...
GO:0000287 F:magnesium ion binding
GO:0004012 F:phospholipid-translocating ATPase activity
GO:0006754 P:ATP biosynthetic process
GO:0015914 P:phospholipid transport

References (1)

[1] “A subfamily of P-type ATPases with aminophospholipid transporting activity.”  Tang X.et.al.   8633245

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MPTMRRTVSE IRSRAEGYEK TDDVSEKTSL ADQEEIRTIF INQPQLTKFC NNHVSTAKYN 
61:	IITFLPRFLY SQFRRAANSF FLFIALLQQI PDVSPTGRYT TLVPLLFILA VAAIKEIIED 
121:	IKRHKADNAV NKKQTQVLRN GAWEIVHWEK VNVGDIVIIK GKEYIPADTV LLSSSEPQAM 
181:	CYIETSNLDG ETNLKIRQGL PATSDIKDID SLMRLSGRIE CESPNRHLYD FVGNIRLDGR 
241:	STVPLGADQI LLRGAQLRNT QWVHGIVVYT GHDTKLMQNS TSPPLKLSNV ERITNVQILI 
301:	LFCILIAMSL VCSVGSAIWN RRHSGRDWYL NLNYGGANNF GLNFLTFIIL FNNLIPISLL 
361:	VTLEVVKFTQ AYFINWDLDM HYEPTDTAAM ARTSNLNVEL GQVKYIFSDK TGTLTCNVMQ 
421:	FKKCTIAGVA YGQNSQFGDE KTFSDSSLLE NLQNNHPTAP IICEFLTMMA VCHTAVPERE 
481:	GDKIIYQAAS PDEGALVRAA KQLNFVFTGR TPDSVIIDSL GQEERYELLN VLEFTSARKR 
541:	MSVIVRTPSG KLRLYCKGAD TVIYDRLAET SKYKEITLKH LEQFATEGLR TLCFAVAEIS 
601:	ESDFQEWRAV YHRASTSVQN RLLKLEESYE LIEKNLQLLG ATAIEDKLQD QVPETIETLM 
661:	KADIKIWILT GDKQETAINI GHSCKLRRKN MGMIVINEGS LDGTRETLSR HCTTLGDALR 
721:	KENDFALIID GKTLKYALTF GVRQYFLDLA LSCKAVICCR VSPLQKSEVV EMVKKQVKVI 
781:	TLAIGDGAND VSMIQTAHVG VGISGNEGLQ AANSSDYSIA QFKYLKNLLM VHGAWNYNRG 
841:	SKCILYCFYK NIVLYIIEIW FAFVNGFSGQ ILFERWCIGL YNVMFTAMPP LTLGIFERSC 
901:	RKEYMLKYPE LYKTSQNALD FNTKVFWVHC LNGLFHSVIL FWFPLKALQY GTVFENGRTS 
961:	DYLLLGNFVY TFVVITVCLK AGLETSYWTW FSHIAIWGSI ALWVVFFGIY SSLWPAVPMA 
1021:	PDMSGEAAML FSSGVFWMGL LFIPVASLLL DVVYKVIKRT AFKTLVDEVQ ELEAKSQDPG 
1081:	AVVLGKSLTE RAQLLKNVFK KNHVNLYRSE SLQQNLLHGY AFSQDENGIV SQSEVIRAYD 
1141:	TTKQRPDEW