3.A.3.8.31
Guanylate cyclase α/β subunit(s) (Wunderlich 2022) with 4226 aas and about 22 TMSs in a possible 2 + 2 + 6 + 6 + 6 TMS arrangement. It has a large phospholipid flippase domain at the N-terminus, a series of at least 3 (partial) repeats, and an atrial natriuretic peptide repcetor domain at the C-terminus. The functionalities of this protein have not been examined.
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| Accession Number: | Q8IHY1 |
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| Protein Name: | Guanylate cyclase alpha |
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| Length: | 4226 |
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| Molecular Weight: | 496021.00 |
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| Species: | Plasmodium falciparum (isolate 3D7) [36329] |
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| Number of TMSs: | 16 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
phospholipid, ATP |
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1: MSDSKKHYNE SNVRYKVKYS GKIFGNNMKK LNENNNHDFT TAEAAWMEKK KKLYKDTNNQ
61: PLWDFRKIQI NPTETDELIS FPSNKICSKN YGKYSFIFKG LYEQFLRLPN IWFLLISLLE
121: FIPQYQNLSN YMYYSKHSSF FLLLFFICVS IIKNIYEDSR RSNIDYQINN RLCHMLDGPN
181: SQLKAVRWME LSVGSIIRLI ENEQVPADIL LLSCNNSEGV VYIETSLLNG ETNLNKKYCV
241: NETRNETSIY AISNIRGRIV CEKPNSNMES FNGSLKLDAH PRATSLSINN VIFKGSHIKN
301: TEYIFGVILY TGNDTKIMKN ISNNKHKLGY VNKELNSYTI IGLIFTFICV FISVLFKWTE
361: DDKFRNGSHF FLITVKDNIC ESIVKYTLLY SNIIPISILI SVDLISILQS ILIENDNHIS
421: TFENYETSEP STIDDMDNEL GDFKMDKSHT FFKKYTYFLN NRSKNFTNNR YSSTNTERAS
481: DFRKSFFGTF DKLKTIKRYF YSIKSKIKSI SQSNTLYNKS SAGGSIIRSD KNKQTTFSKS
541: FIDIFQRTNN NEHSQTLDNN NNNDNNNNNN ICKEKYQNVN NSKNVYVSED SSNNKYKQND
601: YLQKSQEQNE IHSINNNNYN NKNDNNLQTE FSNHNFRINA YKTNRTTKDD TYNNKHISLN
661: SRSKSNQKGI LINSNEINRK KKKNLLQKIF PFFKKKRTNI SEDLSKYVFR RSKQLNINHN
721: NSEKYNLNDY DEYGWGLCLN SNMHGDLGNV DFIFTDKTGT LTNNNMTFNM CSIAGKTYGS
781: KCKNKKKIYN NPKSNNDNKL NSYDKNIFKN KFSSEASIKK ISFVRDFSNN VSSKNDLTLD
841: DPTELISDEG NNYLRDKYEH TSDKKNDTNK NRDGANNSNN NNNKDVSNNK NKNNNNYNYN
901: SNNDYIKQNG ECNIYNNQNN TNNTHNNNIY YDEYNNTNEG NMKNTNVNKD TNSKCNKKDF
961: IINTSDIINN NNNNNNDQKT NNLKYKSSSS WNSKAKKSSY INLNSYNKYQ SFQNSSMLSS
1021: SLSSTCSSET EDENGSQLMY YSSSNYDNLD INNDMDSTKT YSHYTEQNYY NSVKDDKDIN
1081: SEHQRYQQKK TNKQTKNIQQ NQCDQWEDNR YTQESIKNQY FFDRNYQTFL MKQNFPRPKS
1141: FRLNMNSSSV KGRCDFNDTK IYNDLNSQSW RGYYIDEFFK CMTLCHAVTP FIQFDYIRNK
1201: HLTYTNSRSS KGISNNMDRY NINPTTTTTN NNNNNNNINN INNINNNNNN NNNNNNNKQF
1261: SCDYMKNRND IIFETSTDYY ANQDNAKRKR EKTLFDNVSH CGEIQEYRDN KKYRMKRSQT
1321: CSNNRKIFSN QRTLYDYRNM NNNLKNKNSY LRNKLKSKIF LDKSYRKRKK SSGTYKGSDI
1381: CKGIEKKETR RWKRFLHMKG SNNRNIFSRI KDFKSNSIIY NNQDKTNDYK NGYSNNINNN
1441: NSNNYTNEKI NRSFNKRHSA VSFKQMSKEK LIPINNVLSN RCDVESYPNE ELSFSKKKKK
1501: NSEIVSFASG KSDIGFEERT DAGIAGKNME LSYNELEKYK YVKHIDSNNK YINNNNNSIH
1561: MSHMSSNNNT FESHIYFDAI KYQSSSLDEE CLIYSSSFLG YRLVLRNKNT MCIEIDGSFN
1621: KWTIIGVNEF TNRRGKMSIV VKPDSMESGS ILYVKGSDSS ILSLLNLKYS KFLDKKYSRK
1681: RRNKNIQKYK QKREEYNELK SKDINIEEFQ KSKSLSLKNF KNNTPKVLFG ECTLDNNNNN
1741: INKNYKYDKN DKHNNNNNNN NNNSNYSYNY LHDSNNLDAM QNQKYSYAYE DKEDYYYTNN
1801: GECNKYKERY RRLEKQLRKF SVKGLRSMIF AFRYLSEEET IKYKRMYDDA CSSIYNKEQR
1861: LEKVAEEFER DLIYLGITGV KNGLQEKVPK TIDILNQSGI RIWMLTGDNV EYSLHVSFLC
1921: KFLNKHTKIF HAALENSNAK KLKREGMALY ELFQLEKEEK KPYENLCLLV NGRNLQTFLN
1981: YTDLQTHFLN MACTCDVVIA CRITAKQKAF LVQLIKNRLY PTPNTLAIGD GANDIAMIQE
2041: ANIGVSIMTS DCIISAGYSD YCIKKFCYLR KLLFIYGSKH LYTISIILYW NFFKNILLIL
2101: PIFFYQAYAS WSCVKIYPEL LYTFFSIFWV FIPIIYYMFL QHNLNYDILY NIPLFYALSR
2161: RRYNMNCFKF LPWIFEAIFY SMIIYFFAYA ALKENSHLNN GEVITINTFG NICFIGCLLI
2221: SILRLFLEGS LWSPSILITC FGCFLFVFFP SLLFICFAYL SNEYIREVFR QTFLWAPLYV
2281: LLILWFSTCI ISYIFINFTK SILFPNIYNV VNHWLFEQYQ EKHNKNKYIF SLSGKNKFLK
2341: LRKLGKKIKF KFKRNYSKKY DTNVIREHPL LHHTFKSEQD QNKCNEQFSK DPFISNSLLK
2401: SKNCKFKKDS SYSKSNIHVD EEQTYKGLKV VLSEQVVHAK ENLVSFKNEK KNKNNKNTSM
2461: NVNDNIIIKN NNINIKNNDN NNDDNDNDNN NNNNNNDNYN NNDHNKKEFK QKHIQNNYEN
2521: LFNHTQVENN LIKENLSIRN DNNRRDNKNE TDYIKQSDED YEMNPSITSL RKRECINDSK
2581: YIDNKSYDNK ISNNHEEKDG FKSDDRSLIN SNMMDYKNEF TENDTTYSFN DSHMFYDFPS
2641: NSKTTKDYKV INSRIDDSIM ADMKNCLNPL KNTFLVDLLP PGKRFRINED HIYFKNNERM
2701: ENIPEALDVN KKYYHIIQNK AEYYDNDSLS EFSYTSSNSS INNKKKNENT QKEIVKVSHL
2761: INRFTLAFKD MQLESGFQIH KKNKFYKTFT PWYRFIFLLL GVFFLYVWKL ESSLSQLWNM
2821: PSDASTDVFI LFLSLLLELV LLAATVTTFF SNIFIENFNK IISAVVILII TYHVVSYSVT
2881: HIDGVFQAVL FPLYTFVILR LPFVNAVLCN IIFLGLFIIR FNGDHFLDKK GLAHYIPLFI
2941: GVDVFVGFVG YRLEYNQRKN FLLEYSVESS RRKQREILNT MLPPFVVDEM IYSELNEEGI
3001: PISLKAEDIS TVTIIFCDIY DFQNIVASIE PTRLVEVLDR LFLCFDKCTE QFNCTKIETV
3061: FETYLAACGL VKREKDEDEL ENNKYSNNNK NNNNNYYYNR KKKKKKNNNN NNNNNNNNNN
3121: NNNNNNNLNN NNNNNNVNTS DDDGDFFEED DANNHQIYNQ MKGQEDAHDS IDFALSILHV
3181: SSHIKYEKSK MMLKKNDSFE DANDDTHNVN DSFNNDKAEN DNTNTDNNKP TRIRVKVGIH
3241: SGRIIAGVVG SKKPQYALFG DTVNTASRMK TTGKPDYIHI SEATYNLVKD DKTLIYEKKE
3301: TEIKGKGIMT TYLLTSVIGL NYPFLGEHVE KKGHFISELY EDDLSNNLNY DKTQNILGYY
3361: SNKINQNNDS NINEGIINNN MNTFNTIDGD TSNYYVNLKD LSLNDLPNEY IKDVNTHYCE
3421: IIKLRNLKIG TAVGYQLKQK DFYNMTFLNN GLNNDTATNF NQYIESHKDF DDIKDLRIGM
3481: NKLSISDSLY YLNENVIRNE PINEYKNKIK INSVNTNKKS YEDAHLNAGN IIYTNNEYPN
3541: GQNIEEDDDL LLTNHYNKTN VNNNNNNNIY DVSKELIEHN EEDYKNILMC SKRCKNCNET
3601: YCTPNDCNNN DHVYHVMYHR KLSNIKKNYL KNIRKDANIK KDIEKEELNK IHSNKKSFNF
3661: FYLFSYIFKI FPFIGKINKE EKKNKSYKKG EQDKSSKRII ALNSEWIFLK FSDKNLEAKY
3721: RAHFYSNKSN INSIEQALII FLVTFVMQTL ISSTVSIVFI DHKRATQTLH INYFAYWSVR
3781: SVYTFFGFVL WLLFHYRTRP EVSSLLNIKW MIFFLNLLFI SAACVFSIAY LWAISETDQT
3841: TSYTIWMTND TIEFFFYLVI LHHNTGMLFQ TCILVDLLFI TMSLTFIATS VVKTITTDST
3901: VLLIPWYVAF NLISTYCKES IDRRTFYANE SAKKTENRAT ELLNDMLPKH VLEEFQQDKL
3961: KLAYTHDRLT FLFADICGFT SWANGVDASE VLTLLQKLFA KFDNDSTKYG LYKLCTIGDA
4021: YVAISEPVTE DNKDYDPVDG TERVLEMAYS MIRIIKEIRE KLYIPNLNMR IGLHYGSCVG
4081: GVIGSGRLRY DLWGIDVLTG NLMESNGIPG KINVSETLKN FLLQQFKNRF IFKPHTTIRV
4141: IYKDVKCFII TDKKEVESSN HSKLLQNKNY LLNKKFSTQN YLVKNIFAKK KHSSISSSKN
4201: IHSYDEKKKK KNDLFYINVN DRQSNL