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4.A.2.1.3 The 2-O-α-mannosyl D-glycerate porter (2-O-α-mannosyl D-glycerate-6-P forming), MngA (HrsA) (Sampaio et al., 2004). The phosphorylated product is hydrolyzed to manose-6-P and glycerate by MngB, an α-mannosidase.
Accession Number:	P54745
Protein Name:	2-O-alpha-mannosyl D-glycerate porter, MngA (HrsA)
Length:	658
Molecular Weight:	69668.00
Species:	Escherichia coli [83333]
Number of TMSs:	9
Location¹ / Topology² / Orientation³:	Cell inner membrane¹ / Multi-pass membrane protein²
Substrate	2-(alpha-D-mannosyl)-D-glyceric acid

DIP:	DIP-9939N
RefSeq:	AP_001368.1 NP_415259.1
Entrez Gene ID:	945355
Pfam:	PF00359 PF02378 PF02302
BioCyc:	EcoCyc:HRSA-MONOMER ECOL168927:B0731-MONOMER
KEGG:	ecj:JW0720 eco:b0731
Gene Ontology GO:0016021 C:integral to membrane GO:0005886 C:plasma membrane GO:0016301 F:kinase activity GO:0008982 F:protein-N(PI)-phosphohistidine-sugar phosph... GO:0005351 F:sugar:hydrogen symporter activity GO:0009401 P:phosphoenolpyruvate-dependent sugar phospho...
References (5) [1] “Isolation and characterization of the heat-responsive genes in Escherichia coli.” Utsumi R.et.al. 9063979 [2] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R.et.al. 9278503 [3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K.et.al. 16738553 [4] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.” Oshima T.et.al. 8905232 [5] “Global topology analysis of the Escherichia coli inner membrane proteome.” Daley D.O.et.al. 15919996

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MVLFYRAHWR DYKNDQVRIM MNLTTLTHRD ALCLNARFTS REEAIHALTQ RLAALGKISS 
61:	TEQFLEEVYR RESLGPTALG EGLAVPHGKT AAVKEAAFAV ATLSEPLQWE GVDGPEAVDL 
121:	VVLLAIPPNE AGTTHMQLLT ALTTRLADDE IRARIQSATT PDELLSALDD KGGTQPSASF 
181:	SNAPTIVCVT ACPAGIAHTY MAAEYLEKAG RKLGVNVYVE KQGANGIEGR LTADQLNSAT 
241:	ACIFAAEVAI KESERFNGIP ALSVPVAEPI RHAEALIQQA LTLKRSDETR TVQQDTQPVK 
301:	SVKTELKQAL LSGISFAVPL IVAGGTVLAV AVLLSQIFGL QDLFNEENSW LWMYRKLGGG 
361:	LLGILMVPVL AAYTAYSLAD KPALAPGFAA GLAANMIGSG FLGAVVGGLI AGYLMRWVKN 
421:	HLRLSSKFNG FLTFYLYPVL GTLGAGSLML FVVGEPVAWI NNSLTAWLNG LSGSNALLLG 
481:	AILGFMCSFD LGGPVNKAAY AFCLGAMANG VYGPYAIFAS VKMVSAFTVT ASTMLAPRLF 
541:	KEFEIETGKS TWLLGLAGIT EGAIPMAIED PLRVIGSFVL GSMVTGAIVG AMNIGLSTPG 
601:	AGIFSLFLLH DNGAGGVMAA IGWFGAALVG AAISTAILLM WRRHAVKHGN YLTDGVMP

4.A.2.1.3
The 2-O-α-mannosyl D-glycerate porter (2-O-α-mannosyl D-glycerate-6-P forming), MngA (HrsA) (Sampaio et al., 2004). The phosphorylated product is hydrolyzed to manose-6-P and glycerate by MngB, an α-mannosidase.

Cross database links:

Gene Ontology

References (5)

External Searches:

Analyze:

4.A.2.1.3The 2-O-α-mannosyl D-glycerate porter (2-O-α-mannosyl D-glycerate-6-P forming), MngA (HrsA) (Sampaio et al., 2004). The phosphorylated product is hydrolyzed to manose-6-P and glycerate by MngB, an α-mannosidase.

Cross database links:

Gene Ontology

References (5)

External Searches:

Analyze:

4.A.2.1.3
The 2-O-α-mannosyl D-glycerate porter (2-O-α-mannosyl D-glycerate-6-P forming), MngA (HrsA) (Sampaio et al., 2004). The phosphorylated product is hydrolyzed to manose-6-P and glycerate by MngB, an α-mannosidase.