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| Accession Number: | Q91VE0 |
| Protein Name: | Long-chain fatty acid transport protein 4 |
| Length: | 643 |
| Molecular Weight: | 72319.00 |
| Species: | [10090] |
| Number of TMSs: | 1 |
| Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
| Substrate | fatty acid |
Cross database links:
| RefSeq: | NP_036119.1 |
|---|---|
| Entrez Gene ID: | 26569 |
| Pfam: | PF00501 |
| KEGG: | mmu:26569 |
Gene Ontology
GO:0031526
C:brush border membrane
GO:0005783
C:endoplasmic reticulum
GO:0016021
C:integral to membrane
GO:0005902
C:microvillus
GO:0004467
F:long-chain-fatty-acid-CoA ligase activity
GO:0000166
F:nucleotide binding
GO:0031957
F:very-long-chain-fatty-acid-CoA ligase activity
GO:0001676
P:long-chain fatty acid metabolic process
GO:0015909
P:long-chain fatty acid transport
GO:0001579
P:medium-chain fatty acid transport
GO:0043588
P:skin development
GO:0042760
P:very-long-chain fatty acid catabolic process
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References (10)[1] “Mouse fatty acid transport protein 4 (FATP4): characterization of the gene and functional assessment as a very long chain acyl-CoA synthetase.” Herrmann T.et.al. 11404000 [2] “The transcriptional landscape of the mammalian genome.” Carninci P.et.al. 16141072 [3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [4] “A family of fatty acid transporters conserved from mycobacterium to man.” Hirsch D.et.al. 9671728 [5] “Identification of the major intestinal fatty acid transport protein.” Stahl A.et.al. 10518211 [6] “Targeted deletion of fatty acid transport protein-4 results in early embryonic lethality.” Gimeno R.E.et.al. 14512415 [7] “Mice with targeted disruption of the fatty acid transport protein 4 (Fatp 4, Slc27a4) gene show features of lethal restrictive dermopathy.” Herrmann T.et.al. 12821645 [8] “Cloning of wrinkle-free, a previously uncharacterized mouse mutation, reveals crucial roles for fatty acid transport protein 4 in skin and hair development.” Moulson C.L.et.al. 12697906 [9] “Enzymatic properties of purified murine fatty acid transport protein 4 and analysis of acyl-CoA synthetase activities in tissues from FATP4 null mice.” Hall A.M.et.al. 15653672 [10] “Comparative biochemical studies of the murine fatty acid transport proteins (FATP) expressed in yeast.” DiRusso C.C.et.al. 15699031
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MLLGASLVGA LLFSKLVLKL PWTQVGFSLL LLYLGSGGWR FIRVFIKTVR RDIFGGMVLL 61: KVKTKVRRYL QERKTVPLLF ASMVQRHPDK TALIFEGTDT HWTFRQLDEY SSSVANFLQA 121: RGLASGNVVA LFMENRNEFV GLWLGMAKLG VEAALINTNL RRDALRHCLD TSKARALIFG 181: SEMASAICEI HASLEPTLSL FCSGSWEPST VPVSTEHLDP LLEDAPKHLP SHPDKGFTDK 241: LFYIYTSGTT GLPKAAIVVH SRYYRMASLV YYGFRMRPDD IVYDCLPLYH SAGNIVGIGQ 301: CLLHGMTVVI RKKFSASRFW DDCIKYNCTI VQYIGELCRY LLNQPPREAE SRHKVRMALG 361: NGLRQSIWTD FSSRFHIPQV AEFYGATECN CSLGNFDSRV GACGFNSRIL SFVYPIRLVR 421: VNEDTMELIR GPDGVCIPCQ PGQPGQLVGR IIQQDPLRRF DGYLNQGANN KKIANDVFKK 481: GDQAYLTGDV LVMDELGYLY FRDRTGDTFR WKGENVSTTE VEGTLSRLLH MADVAVYGVE 541: VPGTEGRAGM AAVASPISNC DLESFAQTLK KELPLYARPI FLRFLPELHK TGTFKFQKTE 601: LRKEGFDPSV VKDPLFYLDA RKGCYVALDQ EAYTRIQAGE EKL