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4.C.1.1.10
Long-chain fatty acid transport protein 4 (FATP-4) (Fatty acid transport protein 4) (EC 6.2.1.-) (Solute carrier family 27 member 4).  FATP4 is one of a family of six transmembrane proteins that facilitate long- and very long-chain fatty acid uptake. FATP4 is expressed in several tissues, including skin. Mutations in human SLC27A4, which encodes FATP4, cause ichthyosis prematurity syndrome, characterized by a thick desquamating epidermis and premature birth (PMID 23271751). There is an inverse correlation between fatty acid transport protein 4 and vision in Leber congenital amaurosis-associated with the RPE65 mutation (Li et al. 2020). Emodin influences expression of its structural gene (Cheng et al. 2021). It is a skeletal muscle protein, involved in fatty acid transport, that influences fatty acid oxidation rates (Maunder et al. 2023).

Accession Number:Q6P1M0
Protein Name:Long-chain fatty acid transport protein 4
Length:643
Molecular Weight:72064.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate fatty acid

Cross database links:

Entrez Gene ID: 10999   
Pfam: PF00501   
KEGG: hsa:10999   

Gene Ontology

GO:0031526 C:brush border membrane
GO:0005789 C:endoplasmic reticulum membrane
GO:0016021 C:integral to membrane
GO:0005902 C:microvillus
GO:0005886 C:plasma membrane
GO:0015245 F:fatty acid transporter activity
GO:0004467 F:long-chain fatty acid-CoA ligase activity
GO:0000166 F:nucleotide binding
GO:0031957 F:very long-chain fatty acid-CoA ligase activity
GO:0044539 P:long-chain fatty acid import
GO:0001676 P:long-chain fatty acid metabolic process
GO:0001579 P:medium-chain fatty acid transport
GO:0007584 P:response to nutrient
GO:0043588 P:skin development
GO:0055085 P:transmembrane transport
GO:0042760 P:very long-chain fatty acid catabolic process

References (8)

[1] “Tissue distribution and cDNA cloning of a human fatty acid transport protein (hsFATP4).”  Fitscher B.A.et.al.   9878842
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “DNA sequence and analysis of human chromosome 9.”  Humphray S.J.et.al.   15164053
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Initial characterization of the human central proteome.”  Burkard T.R.et.al.   21269460
[6] “Genetic and structural evaluation of fatty acid transport protein-4 in relation to markers of the insulin resistance syndrome.”  Gertow K.et.al.   14715877
[7] “Mutations in the fatty acid transport protein 4 gene cause the ichthyosis prematurity syndrome.”  Klar J.et.al.   19631310
[8] “A novel mutation in the fatty acid transport protein 4 gene in a patient initially described as affected by self-healing congenital verruciform hyperkeratosis.”  Morice-Picard F.et.al.   20815031

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MLLGASLVGV LLFSKLVLKL PWTQVGFSLL FLYLGSGGWR FIRVFIKTIR RDIFGGLVLL 
61:	KVKAKVRQCL QERRTVPILF ASTVRRHPDK TALIFEGTDT HWTFRQLDEY SSSVANFLQA 
121:	RGLASGDVAA IFMENRNEFV GLWLGMAKLG VEAALINTNL RRDALLHCLT TSRARALVFG 
181:	SEMASAICEV HASLDPSLSL FCSGSWEPGA VPPSTEHLDP LLKDAPKHLP SCPDKGFTDK 
241:	LFYIYTSGTT GLPKAAIVVH SRYYRMAALV YYGFRMRPND IVYDCLPLYH SAGNIVGIGQ 
301:	CLLHGMTVVI RKKFSASRFW DDCIKYNCTI VQYIGELCRY LLNQPPREAE NQHQVRMALG 
361:	NGLRQSIWTN FSSRFHIPQV AEFYGATECN CSLGNFDSQV GACGFNSRIL SFVYPIRLVR 
421:	VNEDTMELIR GPDGVCIPCQ PGEPGQLVGR IIQKDPLRRF DGYLNQGANN KKIAKDVFKK 
481:	GDQAYLTGDV LVMDELGYLY FRDRTGDTFR WKGENVSTTE VEGTLSRLLD MADVAVYGVE 
541:	VPGTEGRAGM AAVASPTGNC DLERFAQVLE KELPLYARPI FLRLLPELHK TGTYKFQKTE 
601:	LRKEGFDPAI VKDPLFYLDA QKGRYVPLDQ EAYSRIQAGE EKL