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4.C.1.1.13
Bile acyl-CoA synthetase (BACS) (EC 6.2.1.7) (Bile acid-CoA ligase) (BA-CoA ligase) (BAL) (Cholate--CoA ligase) (Fatty acid transport protein 5) (FATP-5) (Fatty-acid-coenzyme A ligase, very long-chain 3) (Solute carrier family 27 member 5) (Very long-chain acyl-CoA synthetase homologue 2) (VLCS-H2) (VLCSH2) (Very long-chain acyl-CoA synthetase-related protein) (VLACS-related) (VLACSR). Psoraleae Fructus ethanol extracts induced hepatotoxicity by damaging mitochondria, reducing fatty acid beta-oxidation levels, and inhibiting fatty acids ingested by bile in part due in part to low level expression of SLC27A5 (Guo et al. 2023).

Accession Number:Q9Y2P5
Protein Name:Bile acyl-CoA synthetase
Length:690
Molecular Weight:75385.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate fatty acid

Cross database links:

Entrez Gene ID: 10998   
Pfam: PF00501   
KEGG: hsa:10998   

Gene Ontology

GO:0009925 C:basal plasma membrane
GO:0030176 C:integral to endoplasmic reticulum membrane
GO:0005792 C:microsome
GO:0043234 C:protein complex
GO:0005524 F:ATP binding
GO:0047747 F:cholate-CoA ligase activity
GO:0015245 F:fatty acid transporter activity
GO:0031957 F:very long-chain fatty acid-CoA ligase activity
GO:0015721 P:bile acid and bile salt transport
GO:0006699 P:bile acid biosynthetic process
GO:0046951 P:ketone body biosynthetic process
GO:0015911 P:plasma membrane long-chain fatty acid transport
GO:0006642 P:triglyceride mobilization
GO:0000038 P:very long-chain fatty acid metabolic process

References (4)

[1] “Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein.”  Steinberg S.J.et.al.   10479480
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “The human liver-specific homolog of very long-chain acyl-CoA synthetase is cholate:CoA ligase.”  Steinberg S.J.et.al.   10749848
[4] “Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling.”  Mihalik S.J.et.al.   11980911

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MGVRQQLALL LLLLLLLWGL GQPVWPVAVA LTLRWLLGDP TCCVLLGLAM LARPWLGPWV 
61:	PHGLSLAAAA LALTLLPARL PPGLRWLPAD VIFLAKILHL GLKIRGCLSR QPPDTFVDAF 
121:	ERRARAQPGR ALLVWTGPGA GSVTFGELDA RACQAAWALK AELGDPASLC AGEPTALLVL 
181:	ASQAVPALCM WLGLAKLGCP TAWINPHGRG MPLAHSVLSS GARVLVVDPD LRESLEEILP 
241:	KLQAENIRCF YLSHTSPTPG VGALGAALDA APSHPVPADL RAGITWRSPA LFIYTSGTTG 
301:	LPKPAILTHE RVLQMSKMLS LSGATADDVV YTVLPLYHVM GLVVGILGCL DLGATCVLAP 
361:	KFSTSCFWDD CRQHGVTVIL YVGELLRYLC NIPQQPEDRT HTVRLAMGNG LRADVWETFQ 
421:	QRFGPIRIWE VYGSTEGNMG LVNYVGRCGA LGKMSCLLRM LSPFELVQFD MEAAEPVRDN 
481:	QGFCIPVGLG EPGLLLTKVV SQQPFVGYRG PRELSERKLV RNVRQSGDVY YNTGDVLAMD 
541:	REGFLYFRDR LGDTFRWKGE NVSTHEVEGV LSQVDFLQQV NVYGVCVPGC EGKVGMAAVQ 
601:	LAPGQTFDGE KLYQHVRAWL PAYATPHFIR IQDAMEVTST FKLMKTRLVR EGFNVGIVVD 
661:	PLFVLDNRAQ SFRPLTAEMY QAVCEGTWRL