4.C.1.1.21
Long-chain-fatty-acid--CoA ligase 4, ACSL4, of 711 aas and 1 N-terminal TMS. It catalyzes the conversion of long-chain fatty acids to their active form ,
acyl-CoA, for both synthesis of cellular lipids, and degradation via
beta-oxidation. It is one of six newly discovered exo- proteins (ACSL4, IGSF8, ITGA2, ITGA5, ITGB3, MYOF) that may serve as lineage specific extracellular vesicle-associated protein biomarkers for the early detection of high grade serous ovarian cancer (Trinidad et al. 2023; Ohkuni et al. 2013). It preferentially activates arachidonate and eicosapentaenoate as substrates (Golej et al. 2011).
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| Accession Number: | O60488 |
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| Protein Name: | Long-chain-fatty-acid--CoA ligase 4 |
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| Length: | 711 |
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| Molecular Weight: | 79188.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Mitochondrion outer membrane1 / Single-pass type III membrane protein2 |
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| Substrate |
fatty acid |
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1: MKLKLNVLTI ILLPVHLLIT IYSALIFIPW YFLTNAKKKN AMAKRIKAKP TSDKPGSPYR
61: SVTHFDSLAV IDIPGADTLD KLFDHAVSKF GKKDSLGTRE ILSEENEMQP NGKVFKKLIL
121: GNYKWMNYLE VNRRVNNFGS GLTALGLKPK NTIAIFCETR AEWMIAAQTC FKYNFPLVTL
181: YATLGKEAVV HGLNESEASY LITSVELLES KLKTALLDIS CVKHIIYVDN KAINKAEYPE
241: GFEIHSMQSV EELGSNPENL GIPPSRPTPS DMAIVMYTSG STGRPKGVMM HHSNLIAGMT
301: GQCERIPGLG PKDTYIGYLP LAHVLELTAE ISCFTYGCRI GYSSPLTLSD QSSKIKKGSK
361: GDCTVLKPTL MAAVPEIMDR IYKNVMSKVQ EMNYIQKTLF KIGYDYKLEQ IKKGYDAPLC
421: NLLLFKKVKA LLGGNVRMML SGGAPLSPQT HRFMNVCFCC PIGQGYGLTE SCGAGTVTEV
481: TDYTTGRVGA PLICCEIKLK DWQEGGYTIN DKPNPRGEIV IGGQNISMGY FKNEEKTAED
541: YSVDENGQRW FCTGDIGEFH PDGCLQIIDR KKDLVKLQAG EYVSLGKVEA ALKNCPLIDN
601: ICAFAKSDQS YVISFVVPNQ KRLTLLAQQK GVEGTWVDIC NNPAMEAEIL KEIREAANAM
661: KLERFEIPIK VRLSPEPWTP ETGLVTDAFK LKRKELRNHY LKDIERMYGG K