4.C.1.1.3
Long chain fatty acid transporter/acyl-CoA synthetase, Fat1 or FACL6, of 597 aas and 0 TMSs. It is a peripherally membrane-attached protein that activates a broad spectrum of substrates (Mater et al. 2022). It activates fatty acids and thereby modulates the accumulation of triacylglycerol-containing lipid droplets that are used by Mb as an energy source during dormancy. Substrates include saturated and unsaturated fatty acids (C12-C20), some cholic acid derivatives, and even synthetic fatty acids, such as 9(E)-nitrooleicacid (Mater et al. 2022).
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| Accession Number: | O05307 |
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| Protein Name: | Fat1 aka RV1206 aka MTCI364.18 aka MT1244 |
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| Length: | 597 |
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| Molecular Weight: | 64337.00 |
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| Species: | Mycobacterium tuberculosis [1773] |
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| Location1 / Topology2 / Orientation3: |
Mitochondrion outer membrane1 / Multi-pass membrane protein2 |
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| Substrate |
fatty acid |
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1: MSDYYGGAHT TVRLIDLATR MPRVLADTPV IVRGAMTGLL ARPNSKASIG TVFQDRAARY
61: GDRVFLKFGD QQLTYRDANA TANRYAAVLA ARGVGPGDVV GIMLRNSPST VLAMLATVKC
121: GAIAGMLNYH QRGEVLAHSL GLLDAKVLIA ESDLVSAVAE CGASRGRVAG DVLTVEDVER
181: FATTAPATNP ASASAVQAKD TAFYIFTSGT TGFPKASVMT HHRWLRALAV FGGMGLRLKG
241: SDTLYSCLPL YHNNALTVAV SSVINSGATL ALGKSFSASR FWDEVIANRA TAFVYIGEIC
301: RYLLNQPAKP TDRAHQVRVI CGNGLRPEIW DEFTTRFGVA RVCEFYAASE GNSAFINIFN
361: VPRTAGVSPM PLAFVEYDLD TGDPLRDASG RVRRVPDGEP GLLLSRVNRL QPFDGYTDPV
421: ASEKKLVRNA FRDGDCWFNT GDVMSPQGMG HAAFVDRLGD TFRWKGENVA TTQVEAALAS
481: DQTVEECTVY GVQIPRTGGR AGMAAITLRA GAEFDGQALA RTVYGHLPGY ALPLFVRVVG
541: SLAHTTTFKS RKVELRNQAY GADIEDPLYV LAGPDEGYVP YYAEYPEEVS LGRRPQG