| |
|---|---|
| Accession Number: | O14975 |
| Protein Name: | VLCS aka SLC27A2 aka FACVL1 aka VLACS aka FATP2 |
| Length: | 620 |
| Molecular Weight: | 70312.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 2 |
| Location1 / Topology2 / Orientation3: | Endoplasmic reticulum membrane1 / Multi-pass membrane protein2 |
| Substrate | fatty acid |
Cross database links:
| RefSeq: | NP_001153101.1 NP_003636.2 |
|---|---|
| Entrez Gene ID: | 11001 |
| Pfam: | PF00501 |
| OMIM: |
603247 gene |
| KEGG: | hsa:11001 hsa:11001 |
Gene Ontology
GO:0005789
C:endoplasmic reticulum membrane
GO:0016021
C:integral to membrane
GO:0005782
C:peroxisomal matrix
GO:0005778
C:peroxisomal membrane
GO:0005524
F:ATP binding
GO:0004467
F:long-chain-fatty-acid-CoA ligase activity
GO:0050197
F:phytanate-CoA ligase activity
GO:0070251
F:pristanate-CoA ligase activity
GO:0000038
P:very-long-chain fatty acid metabolic process
GO:0005788
C:endoplasmic reticulum lumen
GO:0030176
C:integral to endoplasmic reticulum membrane
GO:0005779
C:integral to peroxisomal membrane
GO:0005792
C:microsome
GO:0005739
C:mitochondrion
GO:0015245
F:fatty acid transporter activity
GO:0031957
F:very long-chain fatty acid-CoA ligase activity
GO:0006699
P:bile acid biosynthetic process
GO:0001561
P:fatty acid alpha-oxidation
GO:0006635
P:fatty acid beta-oxidation
GO:0044539
P:long-chain fatty acid import
GO:0001676
P:long-chain fatty acid metabolic process
GO:0097089
P:methyl-branched fatty acid metabolic process
GO:0042760
P:very long-chain fatty acid catabolic process
| |
References (12)[1] “Human very-long-chain acyl-CoA synthetase: cloning, topography, and relevance to branched-chain fatty acid metabolism.” Steinberg S.J.et.al. 10198260 [2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [3] “Analysis of the DNA sequence and duplication history of human chromosome 15.” Zody M.C.et.al. 16572171 [4] “Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling.” Mihalik S.J.et.al. 11980911 [5] “A quantitative atlas of mitotic phosphorylation.” Dephoure N.et.al. 18669648 [6] “Human very-long-chain acyl-CoA synthetase: cloning, topography, and relevance to branched-chain fatty acid metabolism.” Steinberg S.J.et.al. 10198260 [7] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [8] “Analysis of the DNA sequence and duplication history of human chromosome 15.” Zody M.C.et.al. 16572171 [9] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [10] “Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling.” Mihalik S.J.et.al. 11980911 | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MLSAIYTVLA GLLFLPLLVN LCCPYFFQDI GYFLKVAAVG RRVRSYGQRR PARTILRAFL 61: EKARQTPHKP FLLFRDETLT YAQVDRRSNQ VARALHDHLG LRQGDCVALL MGNEPAYVWL 121: WLGLVKLGCA MACLNYNIRA KSLLHCFQCC GAKVLLVSPE LQAAVEEILP SLKKDDVSIY 181: YVSRTSNTDG IDSFLDKVDE VSTEPIPESW RSEVTFSTPA LYIYTSGTTG LPKAAMITHQ 241: RIWYGTGLTF VSGLKADDVI YITLPFYHSA ALLIGIHGCI VAGATLALRT KFSASQFWDD 301: CRKYNVTVIQ YIGELLRYLC NSPQKPNDRD HKVRLALGNG LRGDVWRQFV KRFGDICIYE 361: FYAATEGNIG FMNYARKVGA VGRVNYLQKK IITYDLIKYD VEKDEPVRDE NGYCVRVPKG 421: EVGLLVCKIT QLTPFNGYAG AKAQTEKKKL RDVFKKGDLY FNSGDLLMVD HENFIYFHDR 481: VGDTFRWKGE NVATTEVADT VGLVDFVQEV NVYGVHVPDH EGRIGMASIK MKENHEFDGK 541: KLFQHIADYL PSYARPRFLR IQDTIEITGT FKHRKMTLVE EGFNPAVIKD ALYFLDDTAK 601: MYVPMTEDIY NAISAKTLKL