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4.D.1.1.10
The hyaluronan (hyaluronate) synthase1/exporter, HAS1

Accession Number:Q92839
Protein Name:Hyaluronan synthase 1
Length:578
Molecular Weight:64832.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Hyaluronate

Cross database links:

Entrez Gene ID: 3036   
KEGG: hsa:3036    hsa:3036   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0050501 F:hyaluronan synthase activity
GO:0007155 P:cell adhesion
GO:0036120 P:cellular response to platelet-derived growth factor stimulus
GO:0010764 P:negative regulation of fibroblast migration

References (8)

[1] “Molecular cloning of human hyaluronan synthase.”  Itano N.et.al.   8651928
[2] “Functional cloning of the cDNA for a human hyaluronan synthase.”  Shyjan A.M.et.al.   8798544
[3] “The DNA sequence and biology of human chromosome 19.”  Grimwood J.et.al.   15057824
[4] “Large-scale proteomics analysis of the human kinome.”  Oppermann F.S.et.al.   19369195
[5] “Molecular cloning of human hyaluronan synthase.”  Itano N.et.al.   8651928
[6] “Functional cloning of the cDNA for a human hyaluronan synthase.”  Shyjan A.M.et.al.   8798544
[7] “The DNA sequence and biology of human chromosome 19.”  Grimwood J.et.al.   15057824
[8] “Large-scale proteomics analysis of the human kinome.”  Oppermann F.S.et.al.   19369195

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MRQQDAPKPT PAACRCSGLA RRVLTIAFAL LILGLMTWAY AAGVPLASDR YGLLAFGLYG 
61:	AFLSAHLVAQ SLFAYLEHRR VAAAARGPLD AATARSVALT ISAYQEDPAY LRQCLASARA 
121:	LLYPRARLRV LMVVDGNRAE DLYMVDMFRE VFADEDPATY VWDGNYHQPW EPAAAGAVGA 
181:	GAYREVEAED PGRLAVEALV RTRRCVCVAQ RWGGKREVMY TAFKALGDSV DYVQVCDSDT 
241:	RLDPMALLEL VRVLDEDPRV GAVGGDVRIL NPLDSWVSFL SSLRYWVAFN VERACQSYFH 
301:	CVSCISGPLG LYRNNLLQQF LEAWYNQKFL GTHCTFGDDR HLTNRMLSMG YATKYTSRSR 
361:	CYSETPSSFL RWLSQQTRWS KSYFREWLYN ALWWHRHHAW MTYEAVVSGL FPFFVAATVL 
421:	RLFYAGRPWA LLWVLLCVQG VALAKAAFAA WLRGCLRMVL LSLYAPLYMC GLLPAKFLAL 
481:	VTMNQSGWGT SGRRKLAANY VPLLPLALWA LLLLGGLVRS VAHEARADWS GPSRAAEAYH 
541:	LAAGAGAYVG YWVAMLTLYW VGVRRLCRRR TGGYRVQV