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5.A.1.2.8
Cytochrome c-type biogenesis protein (CcdA) of 190 aas and 6 TMSs. The NMR structure of a reduced-state mimic of CcdA that transfers electrons across the inner membrane has been determined (Williamson et al. 2015).  The two cysteine positions in CcdA are separated by 20 Å. Whereas one is accessible to the cytoplasm, the other resides in the protein core, thus implying that conformational exchange is required for periplasmic accessibility, confirmed in vitro. The existence of multiple conformational states was demonstrated, suggesting a four-state model for relaying electrons from cytosolic to periplasmic redox substrates (Williamson et al. 2015).

Accession Number:O29205
Protein Name:Cytochrome C-type biogenesis protein (CcdA)
Length:190
Molecular Weight:20769.00
Species:Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) [224325]
Number of TMSs:6
Substrate electron

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Structure:
2N4X     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLMAFALGIL SVFSPCVLPV VPLIFAGSRG RALDAFLIVA GLTISMLILG YTASLFFGFF 
61:	RVVAMLFLLI FALILLSDEL DEKVSIFASR MTSGLSWKIQ TLPSFFFGML LAFLWLPCIL 
121:	PFAGIAISQT LLSENPLVML SYGLGMAVTI AAVFKMGEKF VKANFQLIRK VTGAIVLLYL 
181:	AYFALTEVLL