5.A.1.2.9
CcdA family member, the thiol:disulfide excange protein, DipZ of 695 aas and 7 TMSs. The 1.9Å resolution x-ray structure of the C-terminal ectodomain of Rv2874 revealed the predicted thioredoxin-like domain with its
conserved Cys-X-X-Cys active-site motif, but this domain is combined with a second domain
with a carbohydrate-binding module (CBM) fold (Goldstone et al. 2016). A cavity in the CBM adjacent to the thioredoxin
active site suggested the presence of a carbohydrate-binding site. Possibly, this allows an expansion of the thioredoxin-domain functionality to
carbohydrate modification.
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| Accession Number: | P9WG63 |
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| Protein Name: | Protein DipZ |
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| Length: | 695 |
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| Molecular Weight: | 74168.00 |
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| Species: | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [83332] |
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| Number of TMSs: | 7 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
carbohydrate, electron |
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1: MVESRRAAAA ASAYASRCGI APATSQRSLA TPPTISVPSG EGRCRCHVAR GAGRDPRRRL
61: RRRRWCGRCG YHSHLTGGEF DVNRLCQQRS RERSCQLVAV PADPRPKRQR ITDVLTLALV
121: GFLGGLITGI SPCILPVLPV IFFSGAQSVD AAQVAKPEGA VAVRRKRALS ATLRPYRVIG
181: GLVLSFGMVT LLGSALLSVL HLPQDAIRWA ALVALVAIGA GLIFPRFEQL LEKPFSRIPQ
241: KQIVTRSNGF GLGLALGVLY VPCAGPILAA IVVAGATATI GLGTVVLTAT FALGAALPLL
301: FFALAGQRIA ERVGAFRRRQ REIRIATGSV TILLAVALVF DLPAALQRAI PDYTASLQQQ
361: ISTGTEIREQ LNLGGIVNAQ NAQLSNCSDG AAQLESCGTA PDLKGITGWL NTPGNKPIDL
421: KSLRGKVVLI DFWAYSCINC QRAIPHVVGW YQAYKDSGLA VIGVHTPEYA FEKVPGNVAK
481: GAANLGISYP IALDNNYATW TNYRNRYWPA EYLIDATGTV RHIKFGEGDY NVTETLVRQL
541: LNDAKPGVKL PQPSSTTTPD LTPRAALTPE TYFGVGKVVN YGGGGAYDEG SAVFDYPPSL
601: AANSFALRGR WALDYQGATS DGNDAAIKLN YHAKDVYIVV GGTGTLTVVR DGKPATLPIS
661: GPPTTHQVVA GYRLASETLE VRPSKGLQVF SFTYG