| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
8.A.102.1.1 | Reticulon-like protein B6 of 253 aas and 4 TMSs, RTNLB6. | Eukaryota |
Viridiplantae, Streptophyta | RTNLB6 of Arabidopsis thaliana (Mouse-ear cress) |
|
8.A.102.1.2 | Reticulon-3, Rtn3, of 964 aas and 3 - 4 TMSs at the C-terminus of the protein. May be involved in membrane trafficking in the early secretory pathway. Rtn3 inhibits BACE1 activity and amyloid precursor protein processing and may induce the caspase-8 cascade and apoptosis. May also favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress, and induces the formation of endoplasmic reticulum tubules (Yamamoto et al. 2014). | Eukaryota |
Metazoa, Chordata | Rtn3 of Mus musculus (Mouse) |
|
8.A.102.1.3 | Reticulon-1 isoform X2, Rtn1, of 433 aas and 4 TMSs. | Eukaryota |
Metazoa, Arthropoda | Rtn1 of Apis mellifera |
|
8.A.102.1.4 | Reticulon-like protein 1, RTN1 of 295 aas and 2 or 4 TMSs, if 2, one is near the N-terminus and one is near the C-terminus; if 4, two are near the N-terminus and 2 are near the C-terminus. It may act together with RTN2 (TC# 8.A.102.1.8, Sey1 (1.N.5.1.6) and/or Lunapark, LNP1 (8.A.109.1.1). | Eukaryota |
Fungi, Ascomycota | RTN1 of Saccharomyces cerevisiae (Baker's yeast) |
|
8.A.102.1.5 | Reticulon-like protein of 216 aas and 4 TMSs. | Eukaryota |
RTN protein of Pfiesteria piscicida (Dinoflagellate) | |
|
8.A.102.1.6 | Reticulon-3B, RTN3B, isoform X5 of 220 aas and 4 TMSs | Eukaryota |
Metazoa, Chordata | RTN3B protein of Oryzias latipes (Japanese rice fish;Japanese killifish) |
|
8.A.102.1.7 | Reticulon-like protein B13, RTNLB13, of 206 aas and 4 TMSs, the smallest of the 21 reticulon-like proteins in A. thaliana (Chow et al. 2018). A curvature-sensing amphipathic (APH) helix in the C-terminus of RTNLB13 is conserved in all endoplasmic reticulum shaping reticulons in Arabidopsis thaliana (Brooks et al. 2021). Reticulons with the closest evolutionary relationship to RTNLB13 contain curvature-sensing APHs in the same location with sequence conservation, but a more distantly-related branch of reticulons developed a ~ 20-residue linker between the transmembrane domain and APH. This may facilitate functional flexibility as previous studies have linked these isoforms not only to ER remodeling but to other cellular activities (Brooks et al. 2021). | Eukaryota |
Viridiplantae, Streptophyta | RTNBLB13 of Arabidopsis thaliana (Mouse-ear cress) |
|
8.A.102.1.8 | Reticulon-like protein 2, RTN2, of 393 aas and 2, 3 or 4 TMSs. Functions together with Sey1 (TC# 1.N.5.1.6) as well as RTN1 (TC# 8.A.102.1.4), YOP1 of the DP1 family and LNP1 (P38878; 8.A.109.1.4) to promote ER membrane fusion and reorganization (Hu and Rapoport 2016). | Eukaryota |
Fungi, Ascomycota | RTN2 of Saccharomyces cerevisiae (Baker's yeast) |
|
8.A.102.1.9 | Reticulon 1, RTN1 or NSP, of 776 aas and 2 C-terminal TMSs. Regluates calcium channel CaV2.2 by direct interaction with domain 4 (Mallmann et al. 2019). | Eukaryota |
Metazoa, Chordata | RTN1 of Homo sapiens |
|
8.A.102.1.10 | Reticulon, a reticulophagy receptor, RTN3 with two C-terminal TMSs and maybe one N-terminal TMS (Yang and Klionsky 2020). | Eukaryota |
Metazoa, Chordata | RTN3 of Ophiophagus hannah (King cobra) (Naja hannah) |
|
8.A.102.2.1 | Eukaryota |
Ciliophora | RTNL protein of Tetrahymena thermophila | |
|
8.A.102.2.2 | Uncharacterized protein of 180 aas and 4 TMSs. | Eukaryota |
Apicomplexa | UP of Plasmodium malariae |
|
8.A.102.2.3 | Putative reticulon domain-containing protein of 219 aas and 4 TMSs. | Eukaryota |
Apicomplexa | Reticulon of Eimeria acervulina (Coccidian parasite) |
|
8.A.102.2.4 | Uncharacterized protein of 188 aas and 4 TMSs. | Eukaryota |
Apicomplexa | UP of Theileria equi |
|
8.A.102.2.5 | Uncharacterized protein of 183 aas and 4 TMSs. | Eukaryota |
Apicomplexa | UP of Cryptosporidium hominis |