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8.A.105.1.1
Ferrooxidase, Hephaestin, HEPH, of 1158 aas with one C-terminal TMS and possible another TMS near the N-terminus. It oxidizes ferrous ion (II) to ferric ion (III), and is involved in iron and possibly copper transport and homeostasis. It promotes iron efflux in associated with ferroportin  1 (TC# 2.A.100.1.4) (Vashchenko and MacGillivray 2013). The distribution of  HEPH in various tissues has been studied (Ahn et al. 2018).

Accession Number:Q9BQS7
Protein Name:Hephaestin
Length:1158
Molecular Weight:130449.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Membrane1 / Single-pass type I membrane protein2
Substrate iron(2+)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MESGHLLWAL LFMQSLWPQL TDGATRVYYL GIRDVQWNYA PKGRNVITNQ PLDSDIVASS 
61:	FLKSDKNRIG GTYKKTIYKE YKDDSYTDEV AQPAWLGFLG PVLQAEVGDV ILIHLKNFAT 
121:	RPYTIHPHGV FYEKDSEGSL YPDGSSGPLK ADDSVPPGGS HIYNWTIPEG HAPTDADPAC 
181:	LTWIYHSHVD APRDIATGLI GPLITCKRGA LDGNSPPQRQ DVDHDFFLLF SVVDENLSWH 
241:	LNENIATYCS DPASVDKEDE TFQESNRMHA INGFVFGNLP ELNMCAQKRV AWHLFGMGNE 
301:	IDVHTAFFHG QMLTTRGHHT DVANIFPATF VTAEMVPWEP GTWLISCQVN SHFRDGMQAL 
361:	YKVKSCSMAP PVDLLTGKVR QYFIEAHEIQ WDYGPMGHDG STGKNLREPG SISDKFFQKS 
421:	SSRIGGTYWK VRYEAFQDET FQEKMHLEED RHLGILGPVI RAEVGDTIQV VFYNRASQPF 
481:	SMQPHGVFYE KDYEGTVYND GSSYPGLVAK PFEKVTYRWT VPPHAGPTAQ DPACLTWMYF 
541:	SAADPIRDTN SGLVGPLLVC RAGALGADGK QKGVDKEFFL LFTVLDENKS WYSNANQAAA 
601:	MLDFRLLSED IEGFQDSNRM HAINGFLFSN LPRLDMCKGD TVAWHLLGLG TETDVHGVMF 
661:	QGNTVQLQGM RKGAAMLFPH TFVMAIMQPD NLGTFEIYCQ AGSHREAGMR AIYNVSQCPG 
721:	HQATPRQRYQ AARIYYIMAE EVEWDYCPDR SWEREWHNQS EKDSYGYIFL SNKDGLLGSR 
781:	YKKAVFREYT DGTFRIPRPR TGPEEHLGIL GPLIKGEVGD ILTVVFKNNA SRPYSVHAHG 
841:	VLESTTVWPL AAEPGEVVTY QWNIPERSGP GPNDSACVSW IYYSAVDPIK DMYSGLVGPL 
901:	AICQKGILEP HGGRSDMDRE FALLFLIFDE NKSWYLEENV ATHGSQDPGS INLQDETFLE 
961:	SNKMHAINGK LYANLRGLTM YQGERVAWYM LAMGQDVDLH TIHFHAESFL YRNGENYRAD 
1021:	VVDLFPGTFE VVEMVASNPG TWLMHCHVTD HVHAGMETLF TVFSRTEHLS PLTVITKETE 
1081:	KAVPPRDIEE GNVKMLGMQI PIKNVEMLAS VLVAISVTLL LVVLALGGVV WYQHRQRKLR 
1141:	RNRRSILDDS FKLLSFKQ