8.A.105.1.3
Zyklopen, or hephaestin-like protein 1 precursor, of 1159 aas. It functions as a ferroxidase and is involved in copper transport and homeostasis (Vashchenko and MacGillivray 2013).
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| Accession Number: | Q6MZM0 |
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| Protein Name: | Hephaestin-like protein 1 |
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| Length: | 1159 |
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| Molecular Weight: | 131603.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MPRKQPAGCI FLLTFLGLSG LVGTVTRTYY IGIVEEYWNY VPQGKNVITG KSFTEDKLAT
61: LFLERGPNRI GSIYKKAVYR RFTDGTYSIE IPKPPWLGFL GPILRAEVGD VIVIHLKNFA
121: SRPYSLHPHG VFYNKDSEGA LYPDGTSGRN KNDDMVPPGK NYTYVWPVRE EYAPTPADAN
181: CLTWVYHSHI DAPKDICSGL IGPLLVCKEG ILNRYSGTRN DVDREFVIMF TLVDENQSWY
241: LNENIKHFCT NPDSVDKKDA VFQRSNKMHA LNGYLFGNFP EPDMCVGESV SWHLFGMGNE
301: IDIHSIYFYG NTFISRGHRT DVVNLFPATF LTTEMIAENP GKWMITCQVS DHLQAGMLGQ
361: YNVDNCKSDI FYPKMKGQQR RYFIAAEKIL WDYAPQGYNK FSGLPLNASG SDSDLYFTQG
421: DNRIGGKYWK VRYTEFVDAT FTKRKRLSAE EAHLGILGPV IKAEVGDTLL VTFANKADKV
481: YSILPHGVIY DKASDAAPNL DGFVKPGAHV KPGETFTYKW TVPESVSPTA GDPPCLTYLY
541: FSAVDPIKDT SSGLVGPLLV CKKGVLNADG TQKGIDKEFY LLFTVFDENL SRYFDENIQK
601: FIWHPFSIDK EDKEFVKSNR MHAVNGYMYG NQPGLNMCKR DRVSWHLIGL GTDTDMHGIV
661: FQGNTIHLRG THRDSLALFP HMATTAFMQP DHAGIFRVFC ATMPHLSRGM GQIYEVSSCD
721: NRDPSEQRYG MIRTFYIAAE EVEWDYAPNK NWEFEKQHVD ARGERHGDIF MNRTENWIGS
781: QYKKVVYREY TDGEFVEIKA RPPREEHLEL LGPMIHAEVG NTVLIIFKNK ASRPYSISAQ
841: GVEEMDSGKQ FQVPMTKPGE VKTYRWNIPK RSGPGPSDPN CIPWVYYSTV NFVKDTYSGL
901: MGPLITCRKG VLNEKGRRSD VDYEFALLFL VFNENESWYL DDNIKKYLNK DPRDFKRTDD
961: FEESNRMHAI NGKIFGNLHG LIMNEDTMTN WYLLGIGSEV DIHTIHYHAE SFLFKIDKSY
1021: REDVYDLFPG TFQTIELFAD HPGTWLLHCH VSDHIHAGME TTYTVLRNID NRIPYSTTSP
1081: GVASHPATVP SNERPGKEQL YFFGKNLGPT GAKAALVILF IIGLLLLITT VILSLRLCSA
1141: MKQTDYQQVQ SCALPTDAL