8.A.109.1.1
The ER junction-forming protein, Lunapark, LNP1 of 278 aas and possibly 2 N-terminal TMSs or 4 TMSs in a 2 + 2 arrangement with two N-terminal and 2 more C-terminal (Chen et al. 2012). LNP1 aids in membrane fusion and maintenance of the endoplasmic reticulum (Casey et al. 2015). Works in conjunction with the ER shaping
proteins (reticulons RTN1 and RTN2 (TC# 8.A.102), YOP1), and in antagonism to SEY1 to
maintain the network in a dynamic equilibrium. May counterbalance
SEY1-directed polygon formation by promoting polygon loss through ring
closure (Chen et al. 2012).
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| Accession Number: | P38878 |
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| Protein Name: | Endoplasmic reticulum junction formation protein lunapark |
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| Length: | 278 |
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| Molecular Weight: | 32063.00 |
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| Species: | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MFSALGKWVR GSRNDKDFVT KYTADLSQIT SQIHQLDVAL KKSQSILSQW QSNLTFYGIA
61: LTVLALSYTY WEYHGYRPYL VVTALLCIGS LILFKWALTK LYAFYNNNRL RKLAKLRAIH
121: QKKLEKLKEE THYNATSSII QRFSSGEDQN DDAMVLLDDE LNAKYQELNN LKTELEKFKK
181: ESHVKGLKKE DSDAWFDKII SVLAGGNELD STSSLSPFKK IICPQCHWKS NCYRLASKPI
241: IFICPHCNHK IDEVKEREDA IEAKQPAQPS QSEKEKTK