8.A.109.1.6
TMCC1 (Transmembrane and coiled-coil domains protein 1) of 653 aas and 2 C-terminal TMSs. It is 52% similar to Lunapark of 428 aas and 2 TMSs near the N-terminus of the protein. It is an ER membrane protein that promotesER-associated endosome fission and localizes
to contact sites between the endoplasmic reticulum and endosomes to promote recruitment of the ER to endosome
tubules for fission (Hoyer et al. 2018).Endosome
membrane fission of early and late endosomes is essential to separate
regions destined for lysosomal degradation from carriers to be recycled
to the plasma membrane.
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| Accession Number: | O94876 |
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| Protein Name: | Transmembrane and coiled-coil domains protein 1 |
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| Length: | 653 |
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| Molecular Weight: | 72083.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MEPSGSEQLF EDPDPGGKSQ DAEARKQTES EQKLSKMTHN ALENINVIGQ GLKHLFQHQR
61: RRSSVSPHDV QQIQADPEPE MDLESQNACA EIDGVPTHPT ALNRVLQQIR VPPKMKRGTS
121: LHSRRGKPEA PKGSPQINRK SGQEMTAVMQ SGRPRSSSTT DAPTSSAMME IACAAAAAAA
181: ACLPGEEGTA ERIERLEVSS LAQTSSAVAS STDGSIHTDS VDGTPDPQRT KAAIAHLQQK
241: ILKLTEQIKI AQTARDDNVA EYLKLANSAD KQQAARIKQV FEKKNQKSAQ TILQLQKKLE
301: HYHRKLREVE QNGIPRQPKD VFRDMHQGLK DVGAKVTGFS EGVVDSVKGG FSSFSQATHS
361: AAGAVVSKPR EIASLIRNKF GSADNIPNLK DSLEEGQVDD AGKALGVISN FQSSPKYGSE
421: EDCSSATSGS VGANSTTGGI AVGASSSKTN TLDMQSSGFD ALLHEIQEIR ETQARLEESF
481: ETLKEHYQRD YSLIMQTLQE ERYRCERLEE QLNDLTELHQ NEILNLKQEL ASMEEKIAYQ
541: SYERARDIQE ALEACQTRIS KMELQQQQQQ VVQLEGLENA TARNLLGKLI NILLAVMAVL
601: LVFVSTVANC VVPLMKTRNR TFSTLFLVVF IAFLWKHWDA LFSYVERFFS SPR