TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
8.A.121.1.1









TMEM237 (ALS2CR4) has 408 aas with 4 C-terminal TMSs.  It interacts with the human riboflavin transporter, (h)RFVT-3 (TC#2.A.125.1.2). TMEM237 co-localizes with hRFVT-3 and expressing it caused induces RF uptake, while its knockdown leads to a reduction in uptake. Transfecting TMEM237 into HuTu-80 cells also led to a marked enhancement in hRFVT-3 protein stability, and the level of expression of TMEM237 was reduced following treatment with TNF-alpha (a pro- inflammatory cytokine that inhibits intestinal RF uptake), while its expression was significantly upregulated following treatment with butyrate (an inducer of intestinal RF uptake). Thus, TMEM237 is an interactor with intestinal hRFVT-3, and this interaction affects its stability and activity (Sabui et al. 2019).

Eukaryota
Metazoa
TMEM237 of Homo sapiens
8.A.121.1.2









TMEM237 of 341 aas and 4 C-terminal TMSs.

Eukaryota
Metazoa
TMEM237 of Bemisia tabaci (Sweetpotato whitefly) (Aleurodes tabaci)
8.A.121.1.3









TMEM237 homologue of 523 aas ad 4 C-terminal TMSs.

Eukaryota
Metazoa
TMEM237 of Spodoptera litura
8.A.121.1.4









Rhotekin-2of 747 aas and 5 TMSs, 1 N-terminal and 4 C-terminal as well as several potential TMSs in the middle of the protein.

Eukaryota
Metazoa
Rhotekin-2 of Trichinella spiralis
8.A.121.1.5









TMEM237 of 399 aas and 4 C-terminal TMSs.

Eukaryota
Metazoa
TMEM237 of Caenorhabditis elegans