| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
8.A.126.1.1 | The human nuclear receptor coactivator 7 (NCOA7) of 942 aas. It inhibits the V-type ATPase and therefore has multiple consequences, including inhibiting viral entry into vesicles; see family description (Doyle et al. 2018). COA7-related disorders typically encompass a spectrum of conditions characterized by a variety of major (cerebellar ataxia and axonal polyneuropathy) and minor (leukoencephalopathy, dystonia, and parkinsonism) symptoms, but may also display a dystonia-predominant phenotype (Higuchi et al. 2024). | Eukaryota |
Metazoa, Chordata | NOCOA7 of Homo sapiens |
|
8.A.126.1.2 | GTPase-activating protein (GAP), skywalker (Sky) of 587 aas, for Rab35 which
regulates synaptic vesicle (SV) protein recycling and turnover at neuromuscular junctions (Uytterhoeven et al. 2011). The N-terminal domain of this protein show sequence similarity with family 8.A.87, but the C-terminal domain shows greater seqence similarity with 8.A.116.1.1. | Eukaryota |
Metazoa, Arthropoda | GAP of Drosophila melanogaster (Fruit fly) |
|
8.A.126.1.3 | TBC1 domain family member 24 isoform X1 of 655 aas and 2 C-terminal TMSs. | Eukaryota |
Metazoa, Chordata | TBC1 protein of Marmota flaviventris |
|
8.A.126.1.4 | Uncharacterized TLD family protein of 484 aas and 2 TMSs near the N-terminal domain. | UP of Trichomonas vaginalis |