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TCID	Name	Domain	Kingdom/Phylum	Protein(s)
8.A.128.1.1	Signal adaptor protein and TYRO protein tyrosine kinase-binding protein, KARAP/DAP12/TYROBP, of 113 aas and 2 N-terminal TMSs. It is an adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (Dietrich et al. 2000). See family description and UniProt (O43914) for more information. Human NKG2F can associate with DAP12 (Kim et al. 2004).	Eukaryota	Metazoa, Chordata	KARAP of Homo sapiens
8.A.128.1.2	DAP10 precursor of 81 aas and 1 TMS.	Eukaryota	Metazoa, Chordata	DAP10 of Ictalurus punctatus (channel catfish)
8.A.128.1.3	Uncharacterized protein of 159 aas and 1 TMS		Metazoa, Chordata	UP of Marmota monax (woodchuck)
8.A.128.1.4	Uncharacterized protein of 589 aas and 1 C-terminal TMS. Only the C-terminal residues show sequence similarity with TYROBP.	Eukaryota	Metazoa, Chordata	UP of Chiloscyllium punctatum (brownbanded bambooshark)
8.A.128.1.5	T-cell surface glycoprotein CD3 delta chain of174 aas and 2 TM	Eukaryota	Metazoa, Chordata	CD3 of Mesitornis unicolor (brown roatelo)
8.A.128.1.6	T-cell surface glycoprotein CD3 gamma chain-like isoform X1 of 183 aas and 2 TMSs, one N-terminal and one near the C-terminus.	Eukaryota	Metazoa, Chordata	CD3 of Paralichthys olivaceus (Japanese flounder)
8.A.128.1.7	Receptor-type tyrosine-protein phosphatase H of 788 aas and 2 closely spaced TMSs near the middle of the protein.	Eukaryota	Metazoa, Chordata	PPH of Propithecus coquereli (Coquerel's sifaka)
8.A.128.1.8	Uncharacterized protein of 104 aas and 2 N-terminal TMSs	Eukaryota	Metazoa, Chordata	UP of Takifugu bimaculatus
8.A.128.1.9	Uncharacterized protein of 118 aas and 2 N-terminal TMSs	Eukaryota	Metazoa, Chordata	UP of Cyprinus carpio (common carp)
8.A.128.1.10	T-cell surface glycoprotein CD3, epsilon chain, CD3e, of 207 aas and 1 TMS.	Eukaryota	Metazoa, Chordata	CD3e of Homo sapiens
8.A.128.1.11	Receptor-type tyrosine-protein phosphatase C, PTPRC, LCA or CD45, of 1306 aas and 2 TMSs, one N-terminal and one centrally located. It is a tyrosine-protein phosphatase required for T-cell activation through the antigen receptor (Charbonneau et al. 1988). It acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one (Wu et al. 2002). A prominent CD45 feature is alternative splicing of exons encoding the N-terminus, resulting in the generation of several isoforms (Kountikov et al. 2004). The C-terminal half of the protein has two 300 aa repeats, homologous to a 300 aa segment in the protein with TC# 8.A.128.1.7 (residues 450 to 750).	Eukaryota	Metazoa, Chordata	CD45 of Homo sapiens
8.A.128.1.12	Phogrin, a receptor-type tyrosine-protein phosphatase N2, PTPRN2, of 1015 aas and 2 - 4 TMSs. It plays a role in vesicle-mediated secretory processes (Sengelaub et al. 2016).	Eukaryota	Metazoa, Chordata	Phogrin of Homo sapiens
8.A.128.1.13	Tyrosine-protein phosphatase non-receptor type 2, PTPT or PTPN2 of 415 aas and 1 C-terminal TMS. It protects intestinal barrier function by restricting epithelial tight junction remodeling (Marchelletta et al. 2021). It plays also an important role in glucose homeostasis.	Eukaryota	Metazoa, Chordata	PTPN2 of Homo saiens
8.A.128.2.1	Periaxin of 262 aas and 2 N-terminal TM	Eukaryota	Metazoa, Nematoda	Periaxin of Toxocara canis (dog roundworm)
8.A.128.2.2	Uncharacterized protein of 1516 aas and 1 N-terminal TMS, the region of homology with TC# 8.A.128.2.1.	Eukaryota	Metazoa, Arthropoda	UP of Spodoptera litura
8.A.128.2.3	Periaxin isoform X1 of 1365 aas and 1 N-terminal TMS, the region of homology with TC# 8.A.128.2.1.	Eukaryota	Metazoa, Chordata	Periaxin of Mus musculus
8.A.128.2.4	Uncharacterized protein of 679 aas and 1 N-terminal TMS.	Bacteria	Pseudomonadota	UP of Leucothrix mucor
8.A.128.3.1	Uncharacterized protein of 550 aas and 1 TMS towards the C-terminus, and possibly 1 - 3 TMSs at the N-terminus.	Eukaryota	Fungi, Ascomycota	UP of Pyricularia oryzae
8.A.128.3.2	Uncharacterized protein of 256 aas and 1 or 2 TMSs.	Eukaryota	Fungi, Basidiomycota	UP of Coprinopsis marcescibilis
8.A.128.3.3	Uncharacterized protein of 269 aas and 1 TMS	Eukaryota	Fungi, Ascomycota	UP of Tolypocladium ophioglossoides CBS 100239 (Elaphocordyceps ophioglossoides CBS 100239)
8.A.128.3.4	Uncharacterized protein of 594 aas and 1 - 2 TMSs.	Eukaryota	Fungi, Ascomycota	UP of Exophiala aquamarina
8.A.128.3.5	Uncharacterized protein of 237 aas and 1 TMS	Eukaryota	Fungi, Ascomycota	UP of Lizonia empirigonia
8.A.128.3.6	Uncharacterized protein of 266 aas and 1 TMS	Eukaryota	Fungi, Ascomycota	UP of Epicoccum nigrum
8.A.128.3.7	Uncharacterized protein of 883 aas and 1 TMS		Fungi, Basidiomycota	UP of Crucibulum laeve
8.A.128.3.8	Uncharacterized protein of 276 aas and 1 TMS at aas 160 - 180.	Eukaryota	Fungi, Ascomycota	UP of Setomelanomma holmii
8.A.128.3.9	Uncharacterized protein of 317 aas and 1 TMS	Eukaryota	Fungi, Ascomycota	UP of Trematosphaeria pertusa
8.A.128.3.10	Uncharacterized protein of 356 aas and 1 TMS	Eukaryota	Fungi, Basidiomycota	UP of Fomitiporia mediterranea
8.A.128.3.11	Uncharacterized protein of 404 aas and 1 TMS	Eukaryota	Fungi, Ascomycota	UP of Alternaria alternata
8.A.128.4.1	Uncharacterized protein of 240 aas and 1 TMS	Bacteria	Bacteroidota	UP of Tenacibaculum sp.
8.A.128.4.2	Uncharacterized protein of s189 aas and 1 N-terminal TMS	Bacteria	Pseudomonadota	UP of Thiothrix caldifontis
8.A.128.4.3	Uncharacterized protein of 275 aas and 1 N-terminal TMS	Archaea	Candidatus Bathyarchaeota	UP of Candidatus Bathyarchaeota archaeon (marine sediment metagenome)
8.A.128.4.4	Uncharacterized protein of 242 aas and 3 TMSs in a 2 (N-terminal) + 1 (near the c-terminus) TMS arrangement.		Chloroflexota	UP of Candidatus Thermofonsia Clade 2 bacterium (hot springs metagenome)
8.A.128.4.5	Uncharacterized protein of 221 aas and 1 TMS	Bacteria	Bacteroidota	UP of Rudanella lutea
8.A.128.5.1	Uncharacterized protein of 300 aas and 1 TMS	Eukaryota	Fungi, Ascomycota	UP of Amniculicola lignicola
8.A.128.5.2	Uncharacterized protein of 326 aas and 2 TMSs, N-terminal and towards the C-terminus.	Eukaryota	Fungi, Ascomycota	UP of Tuber borchii (whitish truffle)
8.A.128.5.3	Uncharacterized protein of 314 aas and 2 TMSs. This protein shows sequence similarity not only with other members of 8.A.128.5, but also 8.A.128.1 and 8.A.23.1.	Eukaryota	Fungi, Mucoromycota	UP of Rhizopus microsporus
8.A.128.5.4	Uncharacterized protein of 271 aas and 1 TMS	Eukaryota	Fungi, Ascomycota	UP of Colletotrichum chlorophyti
8.A.128.5.5	Uncharacterized protein of 534 aas and 1 TMS	Eukaryota	Fungi, Ascomycota	UP of Dothistroma septosporum
8.A.128.5.6	Uncharacterized protein of 372 aas and 2 TMSs	Eukaryota	Fungi, Ascomycota	UP of Viridothelium virens
8.A.128.5.7	Uncharacterized protein of 439 aas and 1 TMS	Eukaryota	Fungi, Ascomycota	UP of Aaosphaeria arxii
8.A.128.5.8	Uncharacterized protein of 323 aas and 1 TMS	Eukaryota	Fungi, Ascomycota	UP of Bipolaris oryzae
8.A.128.6.1	Uncharacterized protein of 92 aas and 1 TMS	Bacteria	Pseudomonadota	UP of Enterobacter cloacae complex
8.A.128.6.2	Uncharacterized protein of 89 aas and 1 TMS.	Bacteria	Pseudomonadota	UP of Cronobacter malonaticus
8.A.128.6.3	Uncharacterized protein of 77 aas and 1 TMS	Bacteria	Pseudomonadota	UP of Candidatus Sodalis pierantonius
8.A.128.6.4	Uncharacterized protein of 84 aas and 1 TMS	Bacteria	Pseudomonadota	UP of Ensifer adhaerens (Sinorhizobium morelense = Ensifer morelensis)
8.A.128.6.5	Uncharacterized protein of 94 aas and 1 TMS	Bacteria	Pseudomonadota	UP of Kalamiella piersonii
8.A.128.7.1	T-cell surface glycoprotein CD3 zeta chain, CD247, of 164 aas and 1 TMS. Plays important roles in intrathymic T-cell differentiation and activity-dependent synapse formation of retinal ganglion cells in both the retina and dorsal lateral geniculate nucleus. It is phosphorylated by the ZAP70 protein kinase (Dong et al. 2017).		Metazoa, Chordata
8.A.128.7.2	High affinity immunoglobulin epsilon receptor subunit gamma of 91 aas and 1 TM	Eukaryota	Metazoa, Chordata	Receptor of Terrapene carolina triunguis (Three-toed box turtle)
8.A.128.7.3	T-cell surface glycoprotein CD3 zeta chain-like isoform X1 of 156 aas and 1 TMS	Eukaryota	Metazoa, Chordata	CD3 of Esox lucius (northern pike)
8.A.128.7.4	Uncharacterized protein of 187 aas and 2 TMSs	Eukaryota	Metazoa, Chordata	UP of Perca fluviatilis (European perch)
8.A.128.7.5	Uncharacterized protein of 138 aas and 1 TMS	Eukaryota	Metazoa, Chordata	UP of Danionella translucida
8.A.128.7.6	Uncharacterized protein of 114 aas and 1 TMS	Bacteria	Planctomycetota	UP of Planctomycetes bacterium
8.A.128.7.7	Uncharacterized protein of 132 aas and 1 TMS	Eukaryota	Metazoa, Chordata	UP of Oryzias javanicus (javanese ricefish)
8.A.128.8.1	Podoplanin, APDPN, of 162 aas with one C-terminal TMS (Berger et al. 2023). It does not function as a water channel or as a regulator of aquaporin-type water channels, and does not have any effect on folic acid or amino acid transport (Ma et al. 1998).	Eukaryota	Metazoa, Chordata	Podoplanin of Homo sapiens