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8.A.131.1.12
Hepsin, Hpn or IMPRESS1, of 417 aas and 1 N-terminal TMS. The N-glycan in the scavenger receptor cysteine-rich domain of hepsin promotes intracellular trafficking and cell surface expression (Sun et al. 2020). Hpn is a serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL (Ganesan et al. 2011, Herter et al. 2005). It plays a role in cell growth and maintenance of cell morphology (Torres-Rosado et al. 1993), Ganesan et al. 2011), and also in the proteolytic processing of ACE2 (Heurich et al. 2014). It mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization (Brunati et al. 2015).

Accession Number:P05981
Protein Name:Serine protease hepsin
Length:417
Molecular Weight:45011.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell membrane1 / Single-pass type II membrane protein2
Substrate protein

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FASTA formatted sequence
1:	MAQKEGGRTV PCCSRPKVAA LTAGTLLLLT AIGAASWAIV AVLLRSDQEP LYPVQVSSAD 
61:	ARLMVFDKTE GTWRLLCSSR SNARVAGLSC EEMGFLRALT HSELDVRTAG ANGTSGFFCV 
121:	DEGRLPHTQR LLEVISVCDC PRGRFLAAIC QDCGRRKLPV DRIVGGRDTS LGRWPWQVSL 
181:	RYDGAHLCGG SLLSGDWVLT AAHCFPERNR VLSRWRVFAG AVAQASPHGL QLGVQAVVYH 
241:	GGYLPFRDPN SEENSNDIAL VHLSSPLPLT EYIQPVCLPA AGQALVDGKI CTVTGWGNTQ 
301:	YYGQQAGVLQ EARVPIISND VCNGADFYGN QIKPKMFCAG YPEGGIDACQ GDSGGPFVCE 
361:	DSISRTPRWR LCGIVSWGTG CALAQKPGVY TKVSDFREWI FQAIKTHSEA SGMVTQL