8.A.131.1.12
Hepsin, Hpn or IMPRESS1, of 417 aas and 1 N-terminal TMS. The N-glycan in the scavenger receptor cysteine-rich domain of hepsin promotes intracellular trafficking and cell surface expression (Sun et al. 2020). Hpn is a serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL (Ganesan et al. 2011, Herter et al. 2005). It plays a role in cell growth and maintenance of cell morphology (Torres-Rosado et al. 1993), Ganesan et al. 2011), and also in the proteolytic processing of ACE2 (Heurich et al. 2014). It mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization (Brunati et al. 2015).