TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
8.A.136.1.1









β-arrestin, ARRB1, ARR1, of 418 aas. It functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. activated GPCR undergoes inactivation or desensitization by phosphorylation and binding of β-arrestin resulting in diminution of downstream signals. The desensitized GPCRs are internalized into endosomes, wherein they undergo dephosphorylation or resensitization by  a protein phosphatase to be recycled back to the cell membrane as a naïve GPCR (Gupta et al. 2018). It also controls the locations and activities of certain transport proteins (see family description).

Eukaryota
Metazoa
β-arrestin of Homo sapiens
8.A.136.1.2









Arrestin-2, ARRB2, ARR2, ARB2 of 421 aas.  See family description for functions. β-arrestin2 regulates the cardiac hERG/IKr potassium channel (TC# 1.A.1.20.1; Shi et al. 2019).

Eukaryota
Metazoa
ARRB2 of Homo sapiens
8.A.136.1.3









Arrestin domain-containing protein 3-like of 423 aas.

Eukaryota
Metazoa
Arrestin of Carassius auratus (goldfish)
8.A.136.1.4









Uncharacterized protein of 555 aas

Eukaryota
Metazoa
UP of Protopolystoma xenopodis (roundworm)
8.A.136.1.5









Uncharacterized protein of 638 aas

Eukaryota
Metazoa
UP of Taenia asiatica
8.A.136.1.6









Uncharacterized protein of 690 aas

Eukaryota
Fungi
UP of Periconia macrospinosa
8.A.136.1.7









Uncharacterized protein of 457 aas

Eukaryota
Ichthyosporea
UP of Sphaeroforma arctica
8.A.136.1.8









Uncharacterized protein of 599 aas

Eukaryota
Evosea
UP of Dictyostelium purpureum
8.A.136.1.9









Arrestin-1 of 776 aas

Eukaryota
Metazoa
Arrestin-1 of Echinococcus granulosus
8.A.136.1.10









Arrestin domain-containing protein 3 of 484 aas

Eukaryota
Metazoa
Arrestin 3 of Stomoxys calcitrans
8.A.136.1.11









Arrestin domain containing protein, ARRDC3, of 414 aas. It is an adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and other G protein-coupled receptors (Patwari et al. 2011, Han et al. 2013). It also plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation, and may recruit NEDD4 to ADRB2 (Nabhan et al. 2010). It also regulates uncoupling protein 1 (Ucp1; TC# 2.A.29.3.2) expression in adipose tissue (Carroll et al. 2017).

Eukaryota
Metazoa
ARRDC3 of Homo sapiens