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8.A.138.1.1
Arabidopsis CONSTITUTIVE EXPRESSER of PATHOGENESIS-RELATED 5 (CPR5) has 564 aas and 5 C-terminal TMSs in a 1 + 4 TMS arrangement. It plays a role in gating as part of the nuclear pore complex (NPC), and mutations in CPR5 cause multiple defects, including aberrant trichomes, reduced ploidy levels, reduced growth and enhanced resistance to bacterial and fungal pathogens (Faisal et al. 2020). It regulates negatively the senescence and chlorotic lesions induced by biotic (e.g. pathogens) and abiotic (e.g. sugars, darkness) agents, probably by controlling programmed cell death (pcd) (Yoshida et al. 2002). It is a negative regulator of plant programmed cell death (PCD) and effector-triggered immunity (ETI) (Wang et al. 2014).

Accession Number:Q9LV85
Protein Name:Protein CPR-5
Length:564
Molecular Weight:63112.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEALLLPPSP EPQNQITNPA NSKPNHQSGD VHKDETMMMK KKKDTNPSNL EKRKLKGKKK 
61:	EIMDNDEASS SYCSTSSTSN SNSTKRVTRV VHRLRNPMRL GMARRSVGER QAEKLAKPLG 
121:	FSLAAFANMV IARKNAAGQN VYVDDLVEIF ATLVEESLAN VYGNKLGSFA TNFEQTFSST 
181:	LKILKLTNEC ANPHQSNNND GGSCNLDRST IDGCSDTELF ERETSSATSA YEVMQGSATA 
241:	TSLMNELALF EETLQLSCVP PRSSAMALTT DERFLKEQTR ANDLKTVEIG LQIRELRCKE 
301:	TALGLKFESN NLGKAALELD VSKAAFRAEK FKTELEDTRK EEMVTRIMDW LLVSVFSMLA 
361:	SMVLGVYNFS IKRIEDATSV CDQSEEKSSS WWVPKQVSSI NSGFNTFICR VRVWVQIFFG 
421:	VLMIIVFTYF LNKRSSGTKQ TMPISFIVLF LGIFCGVSGK LCVDTLGGDG KLWLIVWEVF 
481:	CLLQFVANVF TLALYGLMFG PINVTQETRS NRCNSMFPYW ARRSVVYVVI LFVLPVINGL 
541:	LPFATFGEWR DFAMYHLHGG SDYA