8.A.138.1.1
Arabidopsis CONSTITUTIVE EXPRESSER of PATHOGENESIS-RELATED 5
(CPR5) has 564 aas and 5 C-terminal TMSs in a 1 + 4 TMS arrangement. It
plays a role in gating as part of the nuclear pore complex (NPC), and
mutations in CPR5 cause multiple defects, including aberrant trichomes,
reduced ploidy levels, reduced growth and enhanced resistance to
bacterial and fungal pathogens (Faisal et al. 2020). It regulates negatively the senescence and chlorotic
lesions induced by biotic (e.g. pathogens) and abiotic (e.g. sugars,
darkness) agents, probably by controlling programmed cell death (pcd)
(Yoshida et al. 2002). It is a negative regulator of plant programmed cell death (PCD) and effector-triggered immunity (ETI) (Wang et al. 2014).
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| Accession Number: | Q9LV85 |
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| Protein Name: | Protein CPR-5 |
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| Length: | 564 |
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| Molecular Weight: | 63112.00 |
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| Species: | Arabidopsis thaliana (Mouse-ear cress) [3702] |
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| Number of TMSs: | 5 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MEALLLPPSP EPQNQITNPA NSKPNHQSGD VHKDETMMMK KKKDTNPSNL EKRKLKGKKK
61: EIMDNDEASS SYCSTSSTSN SNSTKRVTRV VHRLRNPMRL GMARRSVGER QAEKLAKPLG
121: FSLAAFANMV IARKNAAGQN VYVDDLVEIF ATLVEESLAN VYGNKLGSFA TNFEQTFSST
181: LKILKLTNEC ANPHQSNNND GGSCNLDRST IDGCSDTELF ERETSSATSA YEVMQGSATA
241: TSLMNELALF EETLQLSCVP PRSSAMALTT DERFLKEQTR ANDLKTVEIG LQIRELRCKE
301: TALGLKFESN NLGKAALELD VSKAAFRAEK FKTELEDTRK EEMVTRIMDW LLVSVFSMLA
361: SMVLGVYNFS IKRIEDATSV CDQSEEKSSS WWVPKQVSSI NSGFNTFICR VRVWVQIFFG
421: VLMIIVFTYF LNKRSSGTKQ TMPISFIVLF LGIFCGVSGK LCVDTLGGDG KLWLIVWEVF
481: CLLQFVANVF TLALYGLMFG PINVTQETRS NRCNSMFPYW ARRSVVYVVI LFVLPVINGL
541: LPFATFGEWR DFAMYHLHGG SDYA