8.A.149.1.1
Cytoskeleton-associated protein 4, CKAP4, of 602 aas and one or two adjacent TMSs near the N-terminus. It mediates the anchoring of the endoplasmic reticulum to microtubules (Vedrenne et al. 2005). Palmitoylated CKAP4 regulates mitochondrial functions through an interaction with VDAC2 at ER-mitochondrion contact sites (Harada et al. 2020).
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| Accession Number: | Q07065 |
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| Protein Name: | Cytoskeleton-associated protein 4 |
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| Length: | 602 |
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| Molecular Weight: | 66022.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum membrane1 / Single-pass type II membrane protein2 |
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| Substrate |
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1: MPSAKQRGSK GGHGAASPSE KGAHPSGGAD DVAKKPPPAP QQPPPPPAPH PQQHPQQHPQ
61: NQAHGKGGHR GGGGGGGKSS SSSSASAAAA AAAASSSASC SRRLGRALNF LFYLALVAAA
121: AFSGWCVHHV LEEVQQVRRS HQDFSRQREE LGQGLQGVEQ KVQSLQATFG TFESILRSSQ
181: HKQDLTEKAV KQGESEVSRI SEVLQKLQNE ILKDLSDGIH VVKDARERDF TSLENTVEER
241: LTELTKSIND NIAIFTEVQK RSQKEINDMK AKVASLEESE GNKQDLKALK EAVKEIQTSA
301: KSREWDMEAL RSTLQTMESD IYTEVRELVS LKQEQQAFKE AADTERLALQ ALTEKLLRSE
361: ESVSRLPEEI RRLEEELRQL KSDSHGPKED GGFRHSEAFE ALQQKSQGLD SRLQHVEDGV
421: LSMQVASARQ TESLESLLSK SQEHEQRLAA LQGRLEGLGS SEADQDGLAS TVRSLGETQL
481: VLYGDVEELK RSVGELPSTV ESLQKVQEQV HTLLSQDQAQ AARLPPQDFL DRLSSLDNLK
541: ASVSQVEADL KMLRTAVDSL VAYSVKIETN ENNLESAKGL LDDLRNDLDR LFVKVEKIHE
601: KV