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8.A.15 The K+ Channel Accessory Protein (KChAP) Family

The KChAP family consists of proteins from yeast, plants and animals. The best characterized homologues are from mammals. KChAP interacts with the Kv2 principal subunits of the VIC superfamily, enhancing current levels and surface expression of Kv2 without affecting gating or kinetics. It may function as a chaperone subunit.

References associated with 8.A.15 family:

Coetzee, W.A., Y. Amalillo, J. Chiu, A. Chow, D. Lau, T. McCormack, H. Moreno, M.S. Nadal, A. Ozaita, D. Pountney, M. Saganich, E. Vega-Saenz de Miera, and B. Rudy (1999). Molecular diversity of K+ channels. Ann. N.Y. Acad. Sci USA 868: 233-285. 10414301
Mangubat, E.Z., T.-T. Tseng, and E. Jakobsson. (2003). Phylogenetic analyses of potassium channel auxiliary subunits. J. Mol. Microbiol. Biotechnol. (in press). 12867745