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8.A.152.1.1
The interleukin-2 receptor of 551 aas with 2 TMSs, one N-terminal and one in the middle of the protein (Gesbert et al. 1998). Structure-based cytokine engineering has opened new opportunities for cytokines as drugs, with a focus on the immunotherapeutic cytokines interferon, interleukin-2, and interleukin-4 (Spangler et al. 2015). Depolarization resulted in a decrease in the mobility of IL-2Rα and MHC glycoproteins, whereas hyperpolarization increased their mobility (Nagy et al. 2018).

Accession Number:P14784
Protein Name:Interleukin-2 receptor subunit beta
Length:551
Molecular Weight:61117.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Membrane1 / Single-pass type I membrane protein2
Substrate

Cross database links:

Structure:
2B5I   2ERJ   3QAZ   4GS7   5M5E   6E8K     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAAPALSWRL PLLILLLPLA TSWASAAVNG TSQFTCFYNS RANISCVWSQ DGALQDTSCQ 
61:	VHAWPDRRRW NQTCELLPVS QASWACNLIL GAPDSQKLTT VDIVTLRVLC REGVRWRVMA 
121:	IQDFKPFENL RLMAPISLQV VHVETHRCNI SWEISQASHY FERHLEFEAR TLSPGHTWEE 
181:	APLLTLKQKQ EWICLETLTP DTQYEFQVRV KPLQGEFTTW SPWSQPLAFR TKPAALGKDT 
241:	IPWLGHLLVG LSGAFGFIIL VYLLINCRNT GPWLKKVLKC NTPDPSKFFS QLSSEHGGDV 
301:	QKWLSSPFPS SSFSPGGLAP EISPLEVLER DKVTQLLLQQ DKVPEPASLS SNHSLTSCFT 
361:	NQGYFFFHLP DALEIEACQV YFTYDPYSEE DPDEGVAGAP TGSSPQPLQP LSGEDDAYCT 
421:	FPSRDDLLLF SPSLLGGPSP PSTAPGGSGA GEERMPPSLQ ERVPRDWDPQ PLGPPTPGVP 
481:	DLVDFQPPPE LVLREAGEEV PDAGPREGVS FPWSRPPGQG EFRALNARLP LNTDAYLSLQ 
541:	ELQGQDPTHL V