8.A.152.1.1
The interleukin-2 receptor of 551 aas with 2 TMSs, one N-terminal and one in the middle of the protein (Gesbert et al. 1998). Structure-based cytokine engineering has opened new opportunities for
cytokines as drugs, with a focus on the immunotherapeutic cytokines
interferon, interleukin-2, and interleukin-4 (Spangler et al. 2015). Depolarization resulted in a decrease in the mobility of IL-2Rα and MHC glycoproteins, whereas hyperpolarization increased their mobility (Nagy et al. 2018).
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| Accession Number: | P14784 |
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| Protein Name: | Interleukin-2 receptor subunit beta |
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| Length: | 551 |
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| Molecular Weight: | 61117.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MAAPALSWRL PLLILLLPLA TSWASAAVNG TSQFTCFYNS RANISCVWSQ DGALQDTSCQ
61: VHAWPDRRRW NQTCELLPVS QASWACNLIL GAPDSQKLTT VDIVTLRVLC REGVRWRVMA
121: IQDFKPFENL RLMAPISLQV VHVETHRCNI SWEISQASHY FERHLEFEAR TLSPGHTWEE
181: APLLTLKQKQ EWICLETLTP DTQYEFQVRV KPLQGEFTTW SPWSQPLAFR TKPAALGKDT
241: IPWLGHLLVG LSGAFGFIIL VYLLINCRNT GPWLKKVLKC NTPDPSKFFS QLSSEHGGDV
301: QKWLSSPFPS SSFSPGGLAP EISPLEVLER DKVTQLLLQQ DKVPEPASLS SNHSLTSCFT
361: NQGYFFFHLP DALEIEACQV YFTYDPYSEE DPDEGVAGAP TGSSPQPLQP LSGEDDAYCT
421: FPSRDDLLLF SPSLLGGPSP PSTAPGGSGA GEERMPPSLQ ERVPRDWDPQ PLGPPTPGVP
481: DLVDFQPPPE LVLREAGEEV PDAGPREGVS FPWSRPPGQG EFRALNARLP LNTDAYLSLQ
541: ELQGQDPTHL V