8.A.152.1.12
Erythropoietin receptor, EPOR, of 508 aas and two TMSs, one N-terminal and one central at about residue 260. It is a receptor for erythropoietin (EPO) that mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes, triggering the JAK2/STAT5 signaling cascade. In some cell types, it can also activate STAT1 and STAT3 as well as the LYN tyrosine kinase. The isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling. It is a transmembrane type I receptor with an essential role in the proliferation and differentiation of erythroid progenitors (Tóthová et al. 2023).