8.A.152.2.1
Ciliary neurotrophic factor receptor subunit alpha of 372 aas and 2 TMSs, N- and C-terminal. Along with intraflagellar-transport, targeted changes in sector-wise lipid composition could control receptor localisation and functions in the cilia. Dutta and Ray 2022 discussed how an interplay between ciliary lipid composition, localized lipid modification, and receptor function could contribute to cilia growth and signalling. They argue that lipid modification at the cell-cilium interface could generate an added thrust for a selective exchange of membrane lipids and the transmembrane and membrane-associated proteins.