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8.A.152.2.1
Ciliary neurotrophic factor receptor subunit alpha of 372 aas and 2 TMSs, N- and C-terminal. Along with intraflagellar-transport, targeted changes in sector-wise lipid composition could control receptor localisation and functions in the cilia. Dutta and Ray 2022 discussed how an interplay between ciliary lipid composition, localized lipid modification, and receptor function could contribute to cilia growth and signalling. They argue that lipid modification at the cell-cilium interface could generate an added thrust for a selective exchange of membrane lipids and the transmembrane and membrane-associated proteins.

Accession Number:P26992
Protein Name:Ciliary neurotrophic factor receptor subunit alpha
Length:372
Molecular Weight:40633.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell membrane1 / Lipid-anchor2
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAAPVPWACC AVLAAAAAVV YAQRHSPQEA PHVQYERLGS DVTLPCGTAN WDAAVTWRVN 
61:	GTDLAPDLLN GSQLVLHGLE LGHSGLYACF HRDSWHLRHQ VLLHVGLPPR EPVLSCRSNT 
121:	YPKGFYCSWH LPTPTYIPNT FNVTVLHGSK IMVCEKDPAL KNRCHIRYMH LFSTIKYKVS 
181:	ISVSNALGHN ATAITFDEFT IVKPDPPENV VARPVPSNPR RLEVTWQTPS TWPDPESFPL 
241:	KFFLRYRPLI LDQWQHVELS DGTAHTITDA YAGKEYIIQV AAKDNEIGTW SDWSVAAHAT 
301:	PWTEEPRHLT TEAQAAETTT STTSSLAPPP TTKICDPGEL GSGGGPSAPF LVSVPITLAL 
361:	AAAAATASSL LI