8.A.152.2.8
Prolactin receptor, PRLR, of 622 aas and two TMSs, one at the N-terminus and a second at about residue 240. The prolactin receptor scaffolds Janus kinase 2 via co-structure formation with the phosphoinositide-4,5-bisphosphate (Araya-Secchi et al. 2023). Phosphoinositides, including phosphatidylinositol-4,5-bisphosphate (PIP2),
play a crucial role in controlling key cellular functions such as
membrane and vesicle trafficking, ion channel and transporter activity (Sang et al. 2024).
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| Accession Number: | P16471 |
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| Protein Name: | Prolactin receptor |
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| Length: | 622 |
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| Molecular Weight: | 69506.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Secreted1 |
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| Substrate |
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1: MKENVASATV FTLLLFLNTC LLNGQLPPGK PEIFKCRSPN KETFTCWWRP GTDGGLPTNY
61: SLTYHREGET LMHECPDYIT GGPNSCHFGK QYTSMWRTYI MMVNATNQMG SSFSDELYVD
121: VTYIVQPDPP LELAVEVKQP EDRKPYLWIK WSPPTLIDLK TGWFTLLYEI RLKPEKAAEW
181: EIHFAGQQTE FKILSLHPGQ KYLVQVRCKP DHGYWSAWSP ATFIQIPSDF TMNDTTVWIS
241: VAVLSAVICL IIVWAVALKG YSMVTCIFPP VPGPKIKGFD AHLLEKGKSE ELLSALGCQD
301: FPPTSDYEDL LVEYLEVDDS EDQHLMSVHS KEHPSQGMKP TYLDPDTDSG RGSCDSPSLL
361: SEKCEEPQAN PSTFYDPEVI EKPENPETTH TWDPQCISME GKIPYFHAGG SKCSTWPLPQ
421: PSQHNPRSSY HNITDVCELA VGPAGAPATL LNEAGKDALK SSQTIKSREE GKATQQREVE
481: SFHSETDQDT PWLLPQEKTP FGSAKPLDYV EIHKVNKDGA LSLLPKQREN SGKPKKPGTP
541: ENNKEYAKVS GVMDNNILVL VPDPHAKNVA CFEESAKEAP PSLEQNQAEK ALANFTATSS
601: KCRLQLGGLD YLDPACFTHS FH