Calnexin (CANX) of 627 aas and 2 TMSs, one at the N-terminus, and one near the C-terminus. It is a calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum (ER). It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. It is associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, and may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. (See family description for more details). Calnexin aids in the folding of transport proteins (see TC#s 2.A.22.2.10 and 9.A.49.1.2 and 3) and in the proper insertion of ER membrane glycoproteins via the general secretory pathway (TC# 3.A.5) (Lee et al. 2020). The ER protein CANX (calnexin)-mediates autophagy and protects against alzheimer disease (AD) (Shen et al. 2025).