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8.A.17.2.4 Myelin protein PO. MPZ, of 248 aas and 2 TMSs. PMP22 (1.H.1.2.2) associates with MPZ via their transmembrane domains, and disrupting this interaction causes a loss-of-function phenotype similar to hereditary neuropathy associated with liability to pressure palsies (HNPP) (PMID: 38187781).
Accession Number:	P25189
Protein Name:	Myelin protein P0
Length:	248
Molecular Weight:	27555.00
Species:	Homo sapiens (Human) [9606]
Number of TMSs:	2
Location¹ / Topology² / Orientation³:	Myelin membrane¹ / Single-pass type I membrane protein²
Substrate

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

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FASTA formatted sequence

1:	MAPGAPSSSP SPILAVLLFS SLVLSPAQAI VVYTDREVHG AVGSRVTLHC SFWSSEWVSD 
61:	DISFTWRYQP EGGRDAISIF HYAKGQPYID EVGTFKERIQ WVGDPRWKDG SIVIHNLDYS 
121:	DNGTFTCDVK NPPDIVGKTS QVTLYVFEKV PTRYGVVLGA VIGGVLGVVL LLLLLFYVVR 
181:	YCWLRRQAAL QRRLSAMEKG KLHKPGKDAS KRGRQTPVLY AMLDHSRSTK AVSEKKAKGL 
241:	GESRKDKK

8.A.17.2.4
Myelin protein PO. MPZ, of 248 aas and 2 TMSs. PMP22 (1.H.1.2.2) associates with MPZ via their transmembrane domains, and disrupting this interaction causes a loss-of-function phenotype similar to hereditary neuropathy associated with liability to pressure palsies (HNPP) (PMID: 38187781).

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8.A.17.2.4Myelin protein PO. MPZ, of 248 aas and 2 TMSs. PMP22 (1.H.1.2.2) associates with MPZ via their transmembrane domains, and disrupting this interaction causes a loss-of-function phenotype similar to hereditary neuropathy associated with liability to pressure palsies (HNPP) (PMID: 38187781).

Cross database links:

External Searches:

Analyze: