8.A.17.4.1
Programmed cell death protein 1, PDCD1 or PD1, of 288 aas and one TMS at positions ~170 - 190. It is an inhibitory
receptor on antigen activated T-cells that plays a critical role in
induction and maintenance of immune tolerance to self (Fife and Pauken 2011) and delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2 (Fife and Pauken 2011). Following T-cell receptor (TCR) engagement, PDCD1 associates with
CD3-TCR in the immunological synapse and directly inhibits T-cell
activation. PD-1 is expressed on innate lymphoid-2 (ILC2) cells and plays a role in ani-tumor activities (Jacquelot et al. 2021).
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| Accession Number: | Q15116 |
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| Protein Name: | Programmed cell death protein 1 |
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| Length: | 288 |
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| Molecular Weight: | 31647.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MQIPQAPWPV VWAVLQLGWR PGWFLDSPDR PWNPPTFSPA LLVVTEGDNA TFTCSFSNTS
61: ESFVLNWYRM SPSNQTDKLA AFPEDRSQPG QDCRFRVTQL PNGRDFHMSV VRARRNDSGT
121: YLCGAISLAP KAQIKESLRA ELRVTERRAE VPTAHPSPSP RPAGQFQTLV VGVVGGLLGS
181: LVLLVWVLAV ICSRAARGTI GARRTGQPLK EDPSAVPVFS VDYGELDFQW REKTPEPPVP
241: CVPEQTEYAT IVFPSGMGTS SPARRGSADG PRSAQPLRPE DGHCSWPL