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8.A.17.4.1
Programmed cell death protein 1, PDCD1 or PD1, of 288 aas and one TMS at positions ~170 - 190. It is an inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self (Fife and Pauken 2011) and delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2 (Fife and Pauken 2011). Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation. PD-1 is expressed on innate lymphoid-2 (ILC2) cells and plays a role in ani-tumor activities (Jacquelot et al. 2021).  

Accession Number:Q15116
Protein Name:Programmed cell death protein 1
Length:288
Molecular Weight:31647.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell membrane1 / Single-pass type I membrane protein2
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MQIPQAPWPV VWAVLQLGWR PGWFLDSPDR PWNPPTFSPA LLVVTEGDNA TFTCSFSNTS 
61:	ESFVLNWYRM SPSNQTDKLA AFPEDRSQPG QDCRFRVTQL PNGRDFHMSV VRARRNDSGT 
121:	YLCGAISLAP KAQIKESLRA ELRVTERRAE VPTAHPSPSP RPAGQFQTLV VGVVGGLLGS 
181:	LVLLVWVLAV ICSRAARGTI GARRTGQPLK EDPSAVPVFS VDYGELDFQW REKTPEPPVP 
241:	CVPEQTEYAT IVFPSGMGTS SPARRGSADG PRSAQPLRPE DGHCSWPL