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8.A.170.1.1
The MKS1 (559 aas; 0 TMSs)-B9D2 (175 aas, possibly 1 N-terminal TMS)-B9D1 (204 aas, possibly 1 N-terminal TMS) diffusion barrier (transition zone (TZ)) complex. These proteins are components of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. The complex is involved in centrosome migration to the apical cell surface during early ciliogenesis (Tammachote et al. 2009). It is required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. It may also be required for cell branching morphology. The Meckel Syndrome Protein, Meckelin, may be part of the complex (see TC#9.B.77.1.1). MKS1 interacts with Meckelin (TMEM67; MKS3; Dawe et al. 2007).   

Accession Number:Q9NXB0
Protein Name:Meckel syndrome type 1 protein
Length:559
Molecular Weight:64528.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cytoplasm1
Substrate

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FASTA formatted sequence
1:	MAETVWSTDT GEAVYRSRDP VRNLRLRVHL QRITSSNFLH YQPAAELGKD LIDLATFRPQ 
61:	PTASGHRPEE DEEEEIVIGW QEKLFSQFEV DLYQNETACQ SPLDYQYRQE ILKLENSGGK 
121:	KNRRIFTYTD SDRYTNLEEH CQRMTTAASE VPSFLVERMA NVRRRRQDRR GMEGGILKSR 
181:	IVTWEPSEEF VRNNHVINTP LQTMHIMADL GPYKKLGYKK YEHVLCTLKV DSNGVITVKP 
241:	DFTGLKGPYR IETEGEKQEL WKYTIDNVSP HAQPEEEERE RRVFKDLYGR HKEYLSSLVG 
301:	TDFEMTVPGA LRLFVNGEVV SAQGYEYDNL YVHFFVELPT AHWSSPAFQQ LSGVTQTCTT 
361:	KSLAMDKVAH FSYPFTFEAF FLHEDESSDA LPEWPVLYCE VLSLDFWQRY RVEGYGAVVL 
421:	PATPGSHTLT VSTWRPVELG TVAELRRFFI GGSLELEDLS YVRIPGSFKG ERLSRFGLRT 
481:	ETTGTVTFRL HCLQQSRAFM ESSSLQKRMR SVLDRLEGFS QQSSIHNVLE AFRRARRRMQ 
541:	EARESLPQDL VSPSGTLVS