8.A.18.2.2
CACHD1 of 1274 aas and 2 TMSs. CACHD1 is structurally an α2δ-like protein that functionally increases CaV3 calcium current. CACHD1 increases the presence of CaV3.1 (TC# 1.A.1.11.12) at the cell surface, forms complexes with CaV3.1, and causes an increase in channel open probability.
In hippocampal neurons, CACHD1 causes increases in neuronal firing, so CACHD1 modulates CaV3 activity (Cottrell et al. 2018).
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| Accession Number: | Q5VU97 |
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| Protein Name: | VWFA and cache domain-containing protein 1 |
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| Length: | 1274 |
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| Molecular Weight: | 142290.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MARQPEEEET AVARARRPPL WLLCLVACWL LGAGAEADFS ILDEAQVLAS QMRRLAAEEL
61: GVVTMQRIFN SFVYTEKISN GESEVQQLAK KIREKFNRYL DVVNRNKQVV EASYTAHLTS
121: PLTAIQDCCT IPPSMMEFDG NFNTNVSRTI SCDRLSTTVN SRAFNPGRDL NSVLADNLKS
181: NPGIKWQYFS SEEGIFTVFP AHKFRCKGSY EHRSRPIYVS TVRPQSKHIV VILDHGASVT
241: DTQLQIAKDA AQVILSAIDE HDKISVLTVA DTVRTCSLDQ CYKTFLSPAT SETKRKMSTF
301: VSSVKSSDSP TQHAVGFQKA FQLIRSTNNN TKFQANTDMV IIYLSAGITS KDSSEEDKKA
361: TLQVINEENS FLNNSVMILT YALMNDGVTG LKELAFLRDL AEQNSGKYGV PDRMALPVIK
421: GSMMVLNQLS NLETTVGRFY TNLPNRMIDE AVFSLPFSDE MGDGLIMTVS KPCYFGNLLL
481: GIVGVDVNLA YILEDVTYYQ DSLASYTFLI DDKGYTLMHP SLTRPYLLSE PPLHTDIIHY
541: ENIPKFELVR QNILSLPLGS QIIAVPVNSS LSWHINKLRE TGKEAYNVSY AWKMVQDTSF
601: ILCIVVIQPE IPVKQLKNLN TVPSSKLLYH RLDLLGQPSA CLHFKQLATL ESPTIMLSAG
661: SFSSPYEHLS QPETKRMVEH YTAYLSDNTR LIANPGLKFS VRNEVMATSH VTDEWMTQME
721: MSSLNTYIVR RYIATPNGVL RIYPGSLMDK AFDPTRRQWY LHAVANPGLI SLTGPYLDVG
781: GAGYVVTISH TIHSSSTQLS SGHTVAVMGI DFTLRYFYKV LMDLLPVCNQ DGGNKIRCFI
841: MEDRGYLVAH PTLIDPKGHA PVEQQHITHK EPLVANDILN HPNFVKKNLC NSFSDRTVQR
901: FYKFNTSLAG DLTNLVHGSH CSKYRLARIP GTNAFVGIVN ETCDSLAFCA CSMVDRLCLN
961: CHRMEQNECE CPCECPLEVN ECTGNLTNAE NRNPSCEVHQ EPVTYTAIDP GLQDALHQCV
1021: NSRCSQRLES GDCFGVLDCE WCMVDSDGKT HLDKPYCAPQ KECFGGIVGA KSPYVDDMGA
1081: IGDEVITLNM IKSAPVGPVA GGIMGCIMVL VLAVYAYRHQ IHRRSHQHMS PLAAQEMSVR
1141: MSNLENDRDE RDDDSHEDRG IISNTRFIAA VIERHAHSPE RRRRYWGRSG TESDHGYSTM
1201: SPQEDSENPP CNNDPLSAGV DVGNHDEDLD LDTPPQTAAL LSHKFHHYRS HHPTLHHSHH
1261: LQAAVTVHTV DAEC