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8.A.18.3.2 Voltage-gated Ca²⁺ channel α2δ subunit 4, CACNA2D4 (Kerov et al. 2018). The importance of the cache domains in α₂δ proteins and the basis for their gabapentinoid selectivity has been discussed (Page et al. 2023).
Accession Number:	Q7Z3S7
Protein Name:	Voltage-dependent calcium channel subunit alpha-2/delta-4
Length:	1137
Molecular Weight:	127938.00
Species:	[9606]
Location¹ / Topology² / Orientation³:	Membrane¹ / Single-pass type I membrane protein²
Substrate

RefSeq:	NP_758952.4
Entrez Gene ID:	93589
Pfam:	PF02743 PF00092 PF08399
OMIM:	608171 gene 610478 phenotype
KEGG:	hsa:93589
Gene Ontology GO:0016021 C:integral to membrane GO:0005262 F:calcium channel activity GO:0046872 F:metal ion binding GO:0005244 F:voltage-gated ion channel activity GO:0006816 P:calcium ion transport GO:0050896 P:response to stimulus GO:0007601 P:visual perception
References (5) [1] “Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit.” Qin N.et.al. 12181424 [2] “The full-ORF clone resource of the German cDNA consortium.” Bechtel S.et.al. 17974005 [3] “The finished DNA sequence of human chromosome 12.” Scherer S.E.et.al. 16541075 [4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [5] “Mutation in the auxiliary calcium-channel subunit CACNA2D4 causes autosomal recessive cone dystrophy.” Wycisk K.A.et.al. 17033974

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MVCGCSALLP LPNPRPTMPA TPNFLANPSS SSRWIPLQPM PVAWAFVQKT SALLWLLLLG 
61:	TSLSPAWGQA KIPLETVKLW ADTFGGDLYN TVTKYSGSLL LQKKYKDVES SLKIEEVDGL 
121:	ELVRKFSEDM ENMLRRKVEA VQNLVEAAEE ADLNHEFNES LVFDYYNSVL INERDEKGNF 
181:	VELGAEFLLE SNAHFSNLPV NTSISSVQLP TNVYNKDPDI LNGVYMSEAL NAVFVENFQR 
241:	DPTLTWQYFG SATGFFRIYP GIKWTPDENG VITFDCRNRG WYIQAATSPK DIVILVDVSG 
301:	SMKGLRMTIA KHTITTILDT LGENDFINII AYNDYVHYIE PCFKGILVQA DRDNREHFKL 
361:	LVEELMVKGV GVVDQALREA FQILKQFQEA KQGSLCNQAI MLISDGAVED YEPVFEKYNW 
421:	PDCKVRVFTY LIGREVSFAD RMKWIACNNK GYYTQISTLA DTQENVMEYL HVLSRPMVIN 
481:	HDHDIIWTEA YMDSKLLSSQ AQSLTLLTTV AMPVFSKKNE TRSHGILLGV VGSDVALREL 
541:	MKLAPRYKLG VHGYAFLNTN NGYILSHPDL RPLYREGKKL KPKPNYNSVD LSEVEWEDQA 
601:	ESLRTAMINR ETGTLSMDVK VPMDKGKRVL FLTNDYFFTD ISDTPFSLGV VLSRGHGEYI 
661:	LLGNTSVEEG LHDLLHPDLA LAGDWIYCIT DIDPDHRKLS QLEAMIRFLT RKDPDLECDE 
721:	ELVREVLFDA VVTAPMEAYW TALALNMSEE SEHVVDMAFL GTRAGLLRSS LFVGSEKVSD 
781:	RKFLTPEDEA SVFTLDRFPL WYRQASEHPA GSFVFNLRWA EGPESAGEPM VVTASTAVAV 
841:	TVDKRTAIAA AAGVQMKLEF LQRKFWAATR QCSTVDGPCT QSCEDSDLDC FVIDNNGFIL 
901:	ISKRSRETGR FLGEVDGAVL TQLLSMGVFS QVTMYDYQAM CKPSSHHHSA AQPLVSPISA 
961:	FLTATRWLLQ ELVLFLLEWS VWGSWYDRGA EAKSVFHHSH KHKKQDPLQP CDTEYPVFVY 
1021:	QPAIREANGI VECGPCQKVF VVQQIPNSNL LLLVTDPTCD CSIFPPVLQE ATEVKYNASV 
1081:	KCDRMRSQKL RRRPDSCHAF HPEENAQDCG GASDTSASPP LLLLPVCAWG LLPQLLR

8.A.18.3.2
Voltage-gated Ca²⁺ channel α2δ subunit 4, CACNA2D4 (Kerov et al. 2018). The importance of the cache domains in α₂δ proteins and the basis for their gabapentinoid selectivity has been discussed (Page et al. 2023).

Cross database links:

Gene Ontology

References (5)

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8.A.18.3.2Voltage-gated Ca2+ channel α2δ subunit 4, CACNA2D4 (Kerov et al. 2018). The importance of the cache domains in α2δ proteins and the basis for their gabapentinoid selectivity has been discussed (Page et al. 2023).

Cross database links:

Gene Ontology

References (5)

External Searches:

Analyze:

8.A.18.3.2
Voltage-gated Ca²⁺ channel α2δ subunit 4, CACNA2D4 (Kerov et al. 2018). The importance of the cache domains in α₂δ proteins and the basis for their gabapentinoid selectivity has been discussed (Page et al. 2023).