8.A.183.1.1
The RelA-associated inhibitor, PPP1R13L, AMFR, RNF45. It is an inhibitor of the ASPP protein, iASPP, also called the NFkB-interacting protein 1 (Bergamaschi et al. 2003). See also the family description and Zheng et al. 2022. It is an E3 ubiquitin-protein ligase, AMFR, of 643 aas and 6 - 8 TMSs in the
first (N-terminal) half of the protein. The second (C-terminal) half is
hydrophilic. This E3 ubiquitin-protein ligase mediates the
polyubiquitination of lysine and cysteine residues in target proteins,
such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal
degradation (Shimizu et al. 1999, Liu et al. 2014, Wang et al. 2017). Homologs of AMFR can be found in the ER-RT family (TC# 3.A.16), the PPI family (TC# 3.A.20) and the Rcf family (8.A.112).
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| Accession Number: | Q9UKV5 |
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| Protein Name: | E3 ubiquitin-protein ligase AMFR |
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| Length: | 643 |
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| Molecular Weight: | 72996.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 5 |
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| Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MPLLFLERFP WPSLRTYTGL SGLALLGTII SAYRALSQPE AGPGEPDQLT ASLQPEPPAP
61: ARPSAGGPRA RDVAQYLLSD SLFVWVLVNT ACCVLMLVAK LIQCIVFGPL RVSERQHLKD
121: KFWNFIFYKF IFIFGVLNVQ TVEEVVMWCL WFAGLVFLHL MVQLCKDRFE YLSFSPTTPM
181: SSHGRVLSLL VAMLLSCCGL AAVCSITGYT HGMHTLAFMA AESLLVTVRT AHVILRYVIH
241: LWDLNHEGTW EGKGTYVYYT DFVMELTLLS LDLMHHIHML LFGNIWLSMA SLVIFMQLRY
301: LFHEVQRRIR RHKNYLRVVG NMEARFAVAT PEELAVNNDD CAICWDSMQA ARKLPCGHLF
361: HNSCLRSWLE QDTSCPTCRM SLNIADNNRV REEHQGENLD ENLVPVAAAE GRPRLNQHNH
421: FFHFDGSRIA SWLPSFSVEV MHTTNILGIT QASNSQLNAM AHQIQEMFPQ VPYHLVLQDL
481: QLTRSVEITT DNILEGRIQV PFPTQRSDSI RPALNSPVER PSSDQEEGET SAQTERVPLD
541: LSPRLEETLD FGEVEVEPSE VEDFEARGSR FSKSADERQR MLVQRKDELL QQARKRFLNK
601: SSEDDAASES FLPSEGASSD PVTLRRRMLA AAAERRLQKQ QTS