8.A.187.1.1
Podocalyxin, PODXL or PCCP1 of 558 aas and 2 TMSs, one at the N-terminus and one near the C-terminus. It is involved in the regulation of both adhesion and cell morphology, and consequently in cancer progression (Larrucea et al. 2008). It also influences the expression of various ion transporters including ABCB!/MDR1 (TC# 3.A.1.201.10 (Nagano et al. 2022).
|
| Accession Number: | O00592 |
|---|
| Protein Name: | Podocalyxin |
|---|
| Length: | 558 |
|---|
| Molecular Weight: | 58635.00 |
|---|
| Species: | Homo sapiens (Human) [9606] |
|---|
| Number of TMSs: | 1 |
|---|
| Location1 / Topology2 / Orientation3: |
Apical cell membrane1 |
|---|
| Substrate |
|
|---|
1: MRCALALSAL LLLLSTPPLL PSSPSPSPSP SQNATQTTTD SSNKTAPTPA SSVTIMATDT
61: AQQSTVPTSK ANEILASVKA TTLGVSSDSP GTTTLAQQVS GPVNTTVARG GGSGNPTTTI
121: ESPKSTKSAD TTTVATSTAT AKPNTTSSQN GAEDTTNSGG KSSHSVTTDL TSTKAEHLTT
181: PHPTSPLSPR QPTSTHPVAT PTSSGHDHLM KISSSSSTVA IPGYTFTSPG MTTTLLETVF
241: HHVSQAGLEL LTSGDLPTLA SQSAGITASS VISQRTQQTS SQMPASSTAP SSQETVQPTS
301: PATALRTPTL PETMSSSPTA ASTTHRYPKT PSPTVAHESN WAKCEDLETQ TQSEKQLVLN
361: LTGNTLCAGG ASDEKLISLI CRAVKATFNP AQDKCGIRLA SVPGSQTVVV KEITIHTKLP
421: AKDVYERLKD KWDELKEAGV SDMKLGDQGP PEEAEDRFSM PLIITIVCMA SFLLLVAALY
481: GCCHQRLSQR KDQQRLTEEL QTVENGYHDN PTLEVMETSS EMQEKKVVSL NGELGDSWIV
541: PLDNLTKDDL DEEEDTHL